Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.
Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California, USA.
Addict Biol. 2022 Mar;27(2):e13143. doi: 10.1111/adb.13143. Epub 2022 Feb 1.
The resurgence of interest in using psychedelic drugs, including lysergic acid diethylamide (LSD), in psychiatry has drawn attention to the medically unsupervised practice of 'microdosing'. Thousands of users claim that very low doses of LSD, taken at 3-4-day intervals, improve mood and cognitive function., However, few controlled studies have described the effects of the drug when taken in this way. Here, in a double-blind controlled study, we studied the effects of four repeated doses of LSD tartrate (13 or 26 μg) or placebo, administered to healthy adults at 3-4 day intervals, on mood, cognitive performance and responses to emotional tasks. Participants were randomly assigned to one of three drug conditions: placebo (N = 18), 13 μg LSD (N = 19), or 26 μg LSD (N = 19). They attended four 5-hour drug-administration sessions separated by 3-4 days, followed by a drug-free follow-up session 3-4 days after the last session. LSD (26 μg) produced modest subjective effects including increased ratings of 'feeling a drug effect' and both stimulant-like and LSD-like effects, but the drug did not improve mood or affect performance on psychomotor or most emotional tasks. No residual effects were detected on mood or task performance on the drug-free follow-up session. We conclude that within the context of a controlled setting and a limited number of administrations, repeated low doses of LSD are safe, but produce negligible changes in mood or cognition in healthy volunteers.
人们对使用迷幻药物（包括麦角酸二乙酰胺（LSD））治疗精神疾病重新产生了兴趣，这引起了人们对未经医学监督的“微量用药”实践的关注。成千上万的使用者声称，以 3-4 天的间隔服用非常低剂量的 LSD（LSD，麦角酸二乙基酰胺），可以改善情绪和认知功能。然而，很少有对照研究描述过以这种方式服用该药物的效果。在这里，我们在一项双盲对照研究中，研究了在健康成年人中以 3-4 天的间隔重复服用 LSD 酒石酸盐（13 或 26μg）或安慰剂四次对情绪、认知表现和对情绪任务的反应的影响。参与者被随机分配到三种药物条件之一：安慰剂（N=18）、13μg LSD（N=19）或 26μg LSD（N=19）。他们参加了四次为期 5 小时的药物给药会议，间隔 3-4 天，然后在最后一次会议后 3-4 天进行无药物随访会议。LSD（26μg）产生了适度的主观影响，包括增加了“感觉药物作用”的评分，以及兴奋剂样和 LSD 样的影响，但药物并未改善情绪，也未影响精神运动或大多数情绪任务的表现。在无药物随访会议上，情绪或任务表现均未检测到残留影响。我们的结论是，在受控环境和有限的给药次数下，重复服用低剂量 LSD 是安全的，但在健康志愿者中几乎不会引起情绪或认知的变化。
