Lenti G
MMW Munch Med Wochenschr. 1977 May 13;119(19):639-46.
The significance of genetic factors in the origination of a diabetes mellitus is generally recognized. Besides this, the possibility of a virus etiology and an autoimmune etiology is discussed. The numerous very complex actions of insulin on the cells of liver, muscle and other organs take place with the assistance of special receptors, the number of available receptors probably being important. A great advance in therapy is the development of the monocomponent insulins. They are primarily indicated in the labile forms, especially in infantile and juvenile diabetes, in insulin resistance, for high antiinsulin titiers, insulin allergy, lipoatrophy and microangiopathy. We must wait and see how far transplantation of a pancreas or Langerhans islet cells or the "artificial" pancreas can be used in future treatment.
遗传因素在糖尿病发病中的重要性已得到普遍认可。除此之外，人们还在探讨病毒病因和自身免疫病因的可能性。胰岛素借助特殊受体对肝脏、肌肉及其他器官的细胞发挥众多非常复杂的作用，可用受体的数量可能很重要。治疗方面的一项重大进展是单组分胰岛素的研发。它们主要用于不稳定型糖尿病，尤其是婴幼儿和青少年糖尿病、胰岛素抵抗、高抗胰岛素滴度、胰岛素过敏、脂肪萎缩和微血管病变。胰腺或胰岛细胞移植或“人工”胰腺在未来治疗中的应用前景如何，我们拭目以待。
