Li Chengle, Zhang Hong, Yang Bo
Department of Pharmacy, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, China.
Front Public Health. 2025 Jun 27;13:1598559. doi: 10.3389/fpubh.2025.1598559. eCollection 2025.
Epidemiological studies on acute intoxication contribute to the development of emergency care, particularly in hospital settings. Understanding the demographics and risk factors of acute intoxication aids in designing targeted public health interventions and educational campaigns to reduce its incidence.
The objective of this research was to describe the epidemiological trends and patterns of acute intoxication cases, as well as the types of intoxication, at Tongde Hospital of Zhejiang Province, a general hospital located in eastern China.
A retrospective review of medical records was conducted for all patients presented to the emergency department with acute intoxication at Tongde Hospital of Zhejiang Province between 2020 and 2022. The data collected from the hospital information system included gender, age, visit time, types of intoxication cases, length of hospital stay, treatment administered, and clinical outcomes. Univariate analysis was performed to identify factors associated with suicidal and non-suicidal patients.
During the three-year period from 2020 to 2022, a total of 550 acute intoxication patients were admitted to the emergency department. Females constituted the majority of the cohort, representing 72.3% ( = 398) of the total cases, and the age group of 13 to 40 years made up the largest proportion at 74.7%. The number of cases increased annually, with poisoning incidents varying by month and week. The most common substances involved were drugs (79.6%), followed by alcohol mixed with drugs (5.8%), gases (6.2%), pesticides (3.8%), household chemical products (3.1%), and plants (1.4%). The monthly distribution of cases showed peaks in June, September, and April, while the weekly distribution peaked on Mondays and Thursdays. The mean time interval between toxin exposure and hospital admission was 5.40 ± 9.93 h. Statistical analysis revealed that gender, age, and the type of poisonous substance were all significant factors associated with suicide. After treatment, 80.5% ( = 443) of patients were discharged home within 24 h, while 19.5% ( = 107) required hospitalization.
This study indicates an increasing proportion of suicidal cases among all poisoning incidents, particularly among young women. Drug intoxication was the most common cause, with antidepressants, antipsychotics, and benzodiazepines being the most commonly involved substances. These findings underscore the urgent need for mental health support, pharmaceutical safety measures, and preventive education targeting high-risk groups, particularly young women.
急性中毒的流行病学研究有助于急诊护理的发展，尤其是在医院环境中。了解急性中毒的人口统计学特征和风险因素有助于设计有针对性的公共卫生干预措施和教育活动，以降低其发生率。
本研究的目的是描述位于中国东部的综合性医院浙江省同德医院急性中毒病例的流行病学趋势和模式，以及中毒类型。
对2020年至2022年期间在浙江省同德医院急诊科就诊的所有急性中毒患者的病历进行回顾性研究。从医院信息系统收集的数据包括性别、年龄、就诊时间、中毒病例类型、住院时间、治疗措施和临床结局。进行单因素分析以确定与自杀和非自杀患者相关的因素。
在2020年至2022年的三年期间，共有550例急性中毒患者被收治入急诊科。女性占队列的大多数，占总病例数的72.3%（n = 398），13至40岁年龄组占比最大，为74.7%。病例数逐年增加，中毒事件随月份和周数有所不同。最常见的中毒物质是药物（79.6%），其次是酒精与药物混合（5.8%）、气体（6.2%）、农药（3.8%）、家用化学品（3.1%）和植物（1.4%）。病例的月度分布在6月、9月和4月出现峰值，而每周分布在周一和周四达到峰值。毒素暴露与入院之间的平均时间间隔为5.40 ± 9.93小时。统计分析表明，性别、年龄和有毒物质类型均为与自杀相关的重要因素。治疗后，80.5%（n = 443）的患者在24小时内出院回家，而19.5%（n = 107）的患者需要住院治疗。
本研究表明，在所有中毒事件中，自杀病例的比例在增加，尤其是在年轻女性中。药物中毒是最常见的原因，抗抑郁药、抗精神病药和苯二氮䓬类药物是最常涉及的物质。这些发现强调了迫切需要为高危人群，尤其是年轻女性，提供心理健康支持、药物安全措施和预防教育。
