Batra Divya, Dahiya Surya, Kar Sunil, Arora Ambuj, Arya Ashtha, Imran Ataul H
Department of Conservative Dentistry and Endodontics, National Dental College and Hospital, Derabassi, Punjab, India.
Department of Conservative Dentistry and Endodontics, MM College of Dental Science & Research, Mullana (Ambala), Haryana, India.
J Pharm Bioallied Sci. 2025 Jun;17(Suppl 2):S1535-S1537. doi: 10.4103/jpbs.jpbs_101_25. Epub 2025 Jun 18.
Calcium silicate-based sealers have gained significant attention in endodontics due to their biocompatibility, bioactivity, and sealing ability. Incorporating bioactive glass into these sealers could potentially enhance their physicochemical and biological properties, providing improved clinical outcomes.
Three experimental sealer groups were prepared: group A (calcium silicate-based sealer without reinforcement), group B (calcium silicate-based sealer with 10% bioactive glass), and group C (calcium silicate-based sealer with 20% bioactive glass). The sealers were assessed for their setting time, compressive strength, solubility, and bioactivity. Bioactivity was evaluated by immersing the sealers in simulated body fluid and analyzing hydroxyapatite formation using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). Statistical analysis was conducted using ANOVA with a significance level of < 0.05.
Group C demonstrated the shortest setting time (20 ± 1.5 minutes) compared to group B (25 ± 1.2 minutes) and group A (30 ± 1.8 minutes). Compressive strength was significantly higher in group C (80 ± 5 MPa) than in group B (65 ± 4 MPa) and group A (50 ± 3 MPa). Solubility was lowest in group C (2.5 ± 0.3%) and highest in group A (4.5 ± 0.4%). SEM and EDS analysis revealed a greater formation of hydroxyapatite on the surface of group C, indicating superior bioactivity.
The addition of bioactive glass to calcium silicate-based sealers significantly improved their mechanical properties, reduced solubility, and enhanced bioactivity. The findings suggest that these reinforced sealers could be promising candidates for endodontic applications, providing improved long-term sealing and biological outcomes.
基于硅酸钙的封闭剂因其生物相容性、生物活性和封闭能力在牙髓病学领域受到了广泛关注。将生物活性玻璃加入这些封闭剂中可能会增强其物理化学和生物学性能，从而改善临床效果。
制备了三个实验性封闭剂组：A组（未增强的基于硅酸钙的封闭剂）、B组（含有10%生物活性玻璃的基于硅酸钙的封闭剂）和C组（含有20%生物活性玻璃的基于硅酸钙的封闭剂）。对这些封闭剂的凝固时间、抗压强度、溶解度和生物活性进行了评估。通过将封闭剂浸泡在模拟体液中，并使用扫描电子显微镜（SEM）和能量色散X射线光谱（EDS）分析羟基磷灰石的形成来评估生物活性。使用方差分析进行统计分析，显著性水平<0.05。
与B组（25±1.2分钟）和A组（30±1.8分钟）相比，C组的凝固时间最短（20±1.5分钟）。C组的抗压强度（80±5兆帕）显著高于B组（65±4兆帕）和A组（50±3兆帕）。C组的溶解度最低（2.5±0.3%），A组最高（4.5±0.4%）。SEM和EDS分析显示，C组表面形成的羟基磷灰石更多，表明其生物活性更强。
向基于硅酸钙的封闭剂中添加生物活性玻璃显著改善了其机械性能，降低了溶解度，并增强了生物活性。研究结果表明，这些增强型封闭剂有望用于牙髓病治疗，提供更好的长期封闭效果和生物学结果。
