Mugundhan Varsha, Sinduja Palati, Sekaran Saravanan, Mandal Tanmay, Sharma Srishti, Rana Digpal
Department of Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Department of Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
J Pharm Bioallied Sci. 2025 Jun;17(Suppl 2):S1836-S1838. doi: 10.4103/jpbs.jpbs_272_25. Epub 2025 Jun 18.
The critical-sized bone defect is larger for an organism to heal on its own, and hence, autografting is performed in these cases (e.g., pubic bone), but the amount of tissue regenerated is less; hence, an alternative treatment performed is bone tissue engineering where a temporary constrict is kept, and hence, bone forms and the constrict degrades on its own.
Fabrication of calcium silicate scaffold is performed, and this obtained solution is lyophilized. This zinc is added to enhance its properties as it is a divalent cation that promotes osteoblastic activity. About 1% chitosan and 0.5% zinc calcium silicate are dissolved in acetic acid, poured into a mold froze at - 20°C, and then lyophilized. Spongy scaffold is, therefore, formed, and its properties are analyzed.
SEM analysis, porosity, and swelling ratio were taken to analyze the physio-chemical properties of the scaffold. The swelling ratio when compared shows an increase in zinc-doped scaffold and hence will help in dislodgement of the constriction easily as it helps in easy movement of the nutrients and enhances the tissue formation.
The research on deciphering the role of copper-zinc alloy nanoparticles on osteoblast viability and proliferation has provided valuable insights into their potential effects on bone health and regeneration.
临界尺寸骨缺损对于机体自身愈合而言过大，因此，在这些情况下会进行自体骨移植（例如耻骨），但再生的组织量较少；因此，另一种实施的治疗方法是骨组织工程，即保持一个临时的约束装置，随后，骨形成且约束装置自行降解。
制备硅酸钙支架，所得溶液进行冻干处理。添加锌以增强其性能，因为锌是一种促进成骨细胞活性的二价阳离子。将约1%的壳聚糖和0.5%的锌硅酸钙溶解于乙酸中，倒入模具，在-20°C下冷冻，然后进行冻干处理。由此形成海绵状支架，并对其性能进行分析。
采用扫描电子显微镜分析、孔隙率和溶胀率来分析支架的物理化学性质。相比之下，含锌支架的溶胀率有所增加，因此有助于约束装置的轻松去除，因为它有助于营养物质的顺畅流动并促进组织形成。
关于解读铜锌合金纳米颗粒对成骨细胞活力和增殖作用的研究，为其对骨骼健康和再生的潜在影响提供了有价值的见解。
