Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand.
Department of Oral Sciences, Faculty of Dentistry, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand.
Molecules. 2021 Jan 20;26(3):517. doi: 10.3390/molecules26030517.
The use of platelet concentrates (PCs) in oral and maxillofacial surgery, periodontology, and craniofacial surgery has been reported. While PCs provide a rich reservoir of autologous bioactive growth factors for tissue regeneration, their drawbacks include lack of utility for long-term application, low elastic modulus and strength, and limited storage capability. These issues restrict their broader application. This review focuses on the lyophilization of PCs (LPCs) and how this processing approach affects their biological and mechanical properties for application as a bioactive scaffold for craniofacial tissue regeneration.
A comprehensive search of five electronic databases, including Medline, PubMed, EMBASE, Web of Science, and Scopus, was conducted from 1946 until 2019 using a combination of search terms relating to this topic.
Ten manuscripts were identified as being relevant. The use of LPCs was mostly studied in in vitro and in vivo craniofacial bone regeneration models. Notably, one clinical study reported the utility of LPCs for guided bone regeneration prior to dental implant placement.
Lyophilization can enhance the inherent characteristics of PCs and extends shelf-life, enable their use in emergency surgery, and improve storage and transportation capabilities. In light of this, further preclinical studies and clinical trials are required, as LPCs offer a potential approach for clinical application in craniofacial tissue regeneration.
血小板浓缩物（PCs）已在口腔颌面外科、牙周病学和颅面外科中得到应用。PCs 为组织再生提供了丰富的自体生物活性生长因子储备，但存在缺乏长期应用能力、弹性模量和强度低、储存能力有限等缺点。这些问题限制了它们的更广泛应用。本综述重点介绍了 PCs 的冻干（LPCs）以及这种处理方法如何影响其生物和机械性能，以作为颅面组织再生的生物活性支架应用。
通过组合与该主题相关的搜索词，对包括 Medline、PubMed、EMBASE、Web of Science 和 Scopus 在内的五个电子数据库进行了全面搜索，检索时间从 1946 年持续到 2019 年。
确定了 10 篇相关文献。LPCs 的使用主要在体外和体内颅面骨再生模型中进行了研究。值得注意的是，有一项临床研究报告了在放置牙种植体之前使用 LPCs 进行引导骨再生的效用。
冻干可以增强 PCs 的固有特性并延长保质期，使其能够在急诊手术中使用，并提高储存和运输能力。鉴于此，需要进行进一步的临床前研究和临床试验，因为 LPCs 为颅面组织再生的临床应用提供了一种潜在方法。
