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评估并比较三种不同市售不锈钢冠在不同pH值水平下镍、铬和钛的释放情况:一项研究。

To Evaluate and Compare the Release of Nickel, Chromium, and Titanium from Three Different Commercially Available Stainless steel Crowns at Different pH Levels: An Study.

作者信息

Santapuri Dedeepya Devi, Martha Satyam, Punithavathy R, Haritha K, Manukonda Harika Chowdary, Yadlapalli Manideep

机构信息

Department of Pediatric and Preventive Dentistry, Lenora Institute of Dental Sciences, Rajamahendravaram, Andhra Pradesh, India.

Department of Dental, Indiana University, Indianapolis, Indiana, USA.

出版信息

J Pharm Bioallied Sci. 2025 Jun;17(Suppl 2):S1386-S1388. doi: 10.4103/jpbs.jpbs_1657_24. Epub 2025 Jun 18.

Abstract

BACKGROUND

Stainless steel crowns (SSCs) are widely used in pediatric dentistry; however, their long-term biocompatibility remains a concern due to potential ion release. The oral environment's varying pH and temperature may influence the leaching of metal ions such as nickel, chromium, and titanium.

AIM

To estimate and compare the release of nickel, chromium, and titanium from three commercially available SSCs in artificial saliva at different pH levels (5.5, 6.5, and 7.5) over various time intervals (1, 3, and 6 months).

MATERIALS AND METHODS

Three different brands of SSCs were selected and grouped accordingly. Each group was further subdivided into three subgroups based on the pH of the artificial saliva (5.5, 6.5, and 7.5). The crowns were immersed in artificial saliva and incubated at 37°C. Samples were collected at 1, 3, and 6 months and analyzed using a spectrophotometer to measure the concentration of nickel, chromium, and titanium ions released, reported in parts per million (ppm). Statistical analysis was conducted to assess differences in ion release between groups and across time points.

RESULTS

There was a statistically significant variation in the release of metal ions across different pH levels and time intervals. Nickel and chromium were consistently detected in all groups, while titanium release was minimal. The ion release remained within biologically acceptable limits and was not considered toxic.

CONCLUSION

All tested SSCs released measurable amounts of nickel and chromium, with variations based on pH and duration.

摘要

背景

不锈钢冠(SSCs)在儿童牙科中广泛使用;然而,由于可能的离子释放,其长期生物相容性仍然是一个问题。口腔环境中不断变化的pH值和温度可能会影响镍、铬和钛等金属离子的浸出。

目的

评估并比较三种市售不锈钢冠在不同pH水平(5.5、6.5和7.5)的人工唾液中,在不同时间间隔(1、3和6个月)内镍、铬和钛的释放情况。

材料与方法

选择三种不同品牌的不锈钢冠并相应分组。根据人工唾液的pH值(5.5、6.5和7.5),每组再进一步细分为三个亚组。将牙冠浸入人工唾液中,在37°C下孵育。在1、3和6个月时收集样本,使用分光光度计进行分析,以测量释放的镍、铬和钛离子的浓度,以百万分之一(ppm)报告。进行统计分析以评估组间和不同时间点离子释放的差异。

结果

在不同pH水平和时间间隔下,金属离子的释放存在统计学上的显著差异。在所有组中均持续检测到镍和铬,而钛的释放量极少。离子释放量保持在生物学可接受的范围内,不被认为有毒。

结论

所有测试的不锈钢冠都释放出可测量的镍和铬,其释放量因pH值和持续时间而异。

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