van Joost T, van Everdingen J J
Acta Derm Venereol. 1982;62(6):525-9.
In 76 cases (5.8%) of a population of 1310 cases (examined by patch tests for possible contact dermatitis) a combined (coupled) allergy was found to nickel and cobalt. In 37 out of the 76 cases this combined allergy was associated with clinical dermatitis of the hands. Statistical chi-square analysis revealed that in the original population of patients examined, apart from a strong association between nickel and cobalt reactions, a significant association was also seen extending to the actual level (weakly to strongly positive) of reactions. Moreover this statistically significant association was still seen within the restricted population of combined nickel and cobalt allergics. Statistical association within the population of combined nickel and cobalt allergy between the strength of the Ni and Co reactions and positive reactions to other antigens of routine ICDRG-standard battery was not encountered, however. Positive reactions to cobalt were rare, but extreme. Nickel patients appeared to have about 50 times greater odds of being extreme cobalt positive. The possibility is discussed that facilitation of clinical cobalt allergy might be triggered by a high grade of nickel sensitivity.
在1310例接受斑贴试验以排查可能的接触性皮炎的人群中，有76例（5.8%）被发现对镍和钴存在合并（联合）过敏。在这76例中，有37例这种合并过敏与手部临床性皮炎相关。统计学卡方分析显示，在最初接受检查的患者群体中，除了镍和钴反应之间存在强关联外，还观察到反应的实际水平（从弱阳性到强阳性）之间存在显著关联。此外，在镍和钴合并过敏的受限人群中仍能看到这种具有统计学意义的关联。然而，在镍和钴合并过敏人群中，未发现镍和钴反应强度与常规ICDRG标准系列其他抗原的阳性反应之间存在统计学关联。对钴的阳性反应很少见，但很极端。镍过敏患者出现极端钴阳性的几率似乎大约高50倍。文中讨论了高等级镍敏感性可能引发临床钴过敏易感性增加的可能性。
