Smedler Erik, Salehi Alireza M, Pelanis Aurimantas, Andreazza Ana, Pålsson Erik, Sparding Timea, Landén Mikael
Department of Neuroscience and Physiology, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Neurosci Appl. 2022 Jun 30;1:100108. doi: 10.1016/j.nsa.2022.100108. eCollection 2022.
Mounting evidence indicates mitochondrial dysfunction in bipolar disorder pathophysiology. Here, we employed Proton Nuclear Magnetic Resonance Spectroscopy (H NMR) of cerebrospinal fluid (CSF) samples from well-characterized bipolar disorder patients (n = 67) and healthy controls (n = 55) in order to measure absolute concentrations of multiple metabolites. Focusing on four citric acid cycle metabolites - citrate, glucose, lactate, and pyruvate - we found higher concentrations of both citrate and glucose in patients compared with controls after correcting for age, sex and body mass index, but only the difference in CSF citrate survived correction for multiple comparisons. Within the patient group, CSF citrate concentrations were higher among lithium users than non-users. In conclusion, this report adds further evidence for a mitochondrial dysfunction in bipolar disorder.
越来越多的证据表明线粒体功能障碍在双相情感障碍的病理生理学中起作用。在此，我们对来自特征明确的双相情感障碍患者（n = 67）和健康对照者（n = 55）的脑脊液（CSF）样本进行了质子核磁共振波谱（H NMR）分析，以测量多种代谢物的绝对浓度。聚焦于四种柠檬酸循环代谢物——柠檬酸、葡萄糖、乳酸和丙酮酸——我们发现，在校正年龄、性别和体重指数后，患者体内柠檬酸和葡萄糖的浓度均高于对照组，但只有脑脊液中柠檬酸的差异在多重比较校正后仍然显著。在患者组中，使用锂盐的患者脑脊液中柠檬酸浓度高于未使用者。总之，本报告为双相情感障碍中线粒体功能障碍提供了进一步的证据。
