Peediyakkal Mohamed Zuhail K, Mahmood Nabil, Thurakkal Ashib, Kannappilly Nevin, Koya Sunil Hassan, Sidhique Saifil, Al-Qudah Bara M, Rajha Humam E, Nashwan Abdulqadir J
Critical Care Medicine, Hamad Medical Corporation, Doha, QAT.
Clinical Imaging, Hamad Medical Corporation, Doha, QAT.
Cureus. 2025 Jun 11;17(6):e85819. doi: 10.7759/cureus.85819. eCollection 2025 Jun.
Arnold-Chiari malformation (ACM) is a neuroanatomical disorder characterized by the displacement of cerebellar tonsils through the foramen magnum. While traditionally associated with a spectrum of neurological symptoms, hyponatremic seizures remain a rare and underrecognized presentation of ACM. This manuscript explores the potential pathophysiological mechanisms linking ACM to hyponatremia and presents a clinical case illustrating this unusual association. Although seizures are a well-documented manifestation of various neurological conditions, their occurrence secondary to hyponatremia in ACM patients has not been extensively reported in the literature. By examining this rare complication, we aim to enhance clinical awareness and deepen the understanding of the underlying mechanisms that may contribute to this phenomenon.
阿诺德-奇阿利畸形(ACM)是一种神经解剖学疾病,其特征是小脑扁桃体通过枕骨大孔移位。虽然传统上与一系列神经系统症状相关,但低钠血症性癫痫仍然是ACM一种罕见且未得到充分认识的表现形式。本文探讨了将ACM与低钠血症联系起来的潜在病理生理机制,并呈现了一个临床病例来说明这种不寻常的关联。虽然癫痫是各种神经系统疾病的一种有充分记录的表现,但ACM患者继发于低钠血症的癫痫发作在文献中尚未得到广泛报道。通过研究这种罕见的并发症,我们旨在提高临床认识,并加深对可能导致这一现象的潜在机制的理解。