Ramoun Sherif I, Zaki Sherif A, Issa Amr M, Attalla Ahmed K
Internal Medicine/Pediatrics, Alexandria University Main Hospitals, Alexandria, EGY.
Dermatology, Alexandria University, Alexandria, EGY.
Cureus. 2025 Jun 12;17(6):e85820. doi: 10.7759/cureus.85820. eCollection 2025 Jun.
Type 2 diabetes mellitus (T2DM) is typically considered a progressive condition, but recent evidence suggests potential reversibility through structured lifestyle intervention. We report the case of a 32-year-old Egyptian female with Hashimoto's thyroiditis and newly diagnosed T2DM, confirmed by elevated fasting blood glucose and HbA1c levels. The patient was managed with once-daily metformin, continued levothyroxine, a 500-calorie daily energy deficit, and progressive resistance training three times per week. After 12 months, fasting glucose and HbA1c values decreased below the diagnostic thresholds for diabetes, allowing metformin to be discontinued. Follow-up at one, three, and six months post-intervention confirmed sustained biochemical remission. This case highlights the potential for reversing diabetes in select patients through a combined pharmacological and lifestyle approach.
2型糖尿病（T2DM）通常被认为是一种进行性疾病，但最近的证据表明，通过结构化的生活方式干预有可能实现逆转。我们报告了一例32岁的埃及女性病例，该患者患有桥本甲状腺炎且新诊断为T2DM，空腹血糖和糖化血红蛋白（HbA1c）水平升高证实了这一诊断。患者接受每日一次的二甲双胍治疗，继续服用左甲状腺素，每日能量摄入减少500卡路里，并每周进行三次渐进性抗阻训练。12个月后，空腹血糖和HbA1c值降至糖尿病诊断阈值以下，二甲双胍得以停用。干预后1个月、3个月和6个月的随访证实生化指标持续缓解。该病例突出了通过药物和生活方式相结合的方法使部分患者糖尿病逆转的可能性。
