Kelly John, Karlsen Micaela, Steinke Gregory
Loma Linda University Health, Loma Linda, California (JK).
American College of Lifestyle Medicine, Chesterfield, Missouri (JK, MK).
Am J Lifestyle Med. 2020 Jun 8;14(4):406-419. doi: 10.1177/1559827620930962. eCollection 2020 Jul-Aug.
. The present review represents the position of the American College of Lifestyle Medicine on type 2 diabetes (T2D) and remission treatment. . Research now reveals that sufficiently intensive lifestyle interventions can produce remission of T2D with similar success to bariatric surgery, but with substantially fewer untoward side effects. . A literature review was conducted to examine lifestyle modifications targeting T2D remission, with most studies using a combination of blood glucose markers and treatment history. . There were notable differences in the dosing intensity of lifestyle interventions between therapeutic interventions and subtherapeutic interventions. Studies with therapeutic dosing typically used very low energy diets (600-1100 kcal/day) with a weighted mean remission rate of 49.4%, while studies with subtherapeutic dosing typically used more moderate caloric restrictions (reducing energy intake by 500-600 kcal/day) and the weighted mean remission rate was 6.9%. . Remission should be the clinical goal in T2D treatment, using properly dosed intensive lifestyle interventions as a primary component of medical care for T2D patients.
本综述代表了美国生活方式医学学院对2型糖尿病(T2D)及其缓解治疗的立场。研究现已表明,足够强化的生活方式干预能够使T2D得到缓解,其成功率与减肥手术相当,但不良副作用要少得多。我们进行了一项文献综述,以研究针对T2D缓解的生活方式改变,大多数研究采用了血糖指标和治疗史相结合的方法。治疗性干预与亚治疗性干预在生活方式干预的剂量强度上存在显著差异。采用治疗剂量的研究通常使用极低能量饮食(600 - 1100千卡/天),加权平均缓解率为49.4%,而采用亚治疗剂量的研究通常使用更适度的热量限制(将能量摄入减少500 - 600千卡/天),加权平均缓解率为6.9%。缓解应成为T2D治疗的临床目标,将适当剂量的强化生活方式干预作为T2D患者医疗护理的主要组成部分。