Ruiz-Vall Alejandro, Altamirano-Faus Ana, Bedmar-Gonzalez Nerea, Andres-Lencina Juan Jose
Plastic Surgery, Ilahy Gandia, Gandia, ESP.
Dermatology, Hospital Vega Baja, Alicante, ESP.
Cureus. 2025 Jun 12;17(6):e85829. doi: 10.7759/cureus.85829. eCollection 2025 Jun.
To evaluate the efficacy of ozonated oil compared to conventional wound care in enhancing postoperative wound healing and cosmetic outcomes in bilateral breast surgery. The primary outcomes were pruritus, pain, and scar aesthetics (color, texture, and thickness) at six weeks.
A prospective, self-controlled pilot study was conducted on five female patients undergoing bilateral breast surgery (10 wounds). One breast received conventional care (cleaning with saline and topical antiseptics), while the contralateral breast was treated with topical ozonated oil (Ozoaqua®, Spain). Pain, pruritus, and scar appearance (color, texture, and thickness) were evaluated at six weeks using patient-reported scales (0-10). A blinded physician independently evaluated scar quality. Data were analyzed using paired t-tests and Wilcoxon tests.
Wounds treated with ozonated oil demonstrated significantly lower pain (2.4 ± 1.1 vs. 4.0 ± 1.2; p = 0.011), reduced pruritus (median score 1 vs. 3; p = 0.042), and superior scar color (4.2 ± 0.8 vs. 3.4 ± 0.5; p = 0.05), texture (4.4 ± 0.5 vs. 3.2 ± 0.8; p = 0.03), and thickness (4.0 ± 0.7 vs. 3.0 ± 1.0; p = 0.04). The blinded evaluator favored ozonated oil-treated scars in four out of five cases.
Ozonated oil significantly enhanced wound healing outcomes, reducing pain and pruritus and improving scar aesthetics compared to conventional care. These findings support further investigation through larger randomized trials. Given its low cost and ease of use, ozonated oil may be a valuable adjunct in rural plastic surgery settings where access to postoperative scar management resources is limited.
评估与传统伤口护理相比，臭氧油在双侧乳房手术中促进术后伤口愈合及改善美容效果方面的疗效。主要观察指标为术后六周时的瘙痒、疼痛及瘢痕美观度（颜色、质地和厚度）。
对五名接受双侧乳房手术的女性患者（10个伤口）进行了一项前瞻性、自身对照的试点研究。一侧乳房接受传统护理（用生理盐水清洗并局部使用防腐剂），而对侧乳房则局部使用臭氧油（西班牙的Ozoaqua®）进行治疗。术后六周时，使用患者报告量表（0 - 10分）评估疼痛、瘙痒及瘢痕外观（颜色、质地和厚度）。一名不知情的医生独立评估瘢痕质量。采用配对t检验和威尔科克森检验对数据进行分析。
用臭氧油治疗的伤口疼痛明显减轻（2.4±1.1 vs. 4.0±1.2；p = 0.011），瘙痒减轻（中位数评分1 vs. 3；p = 0.042），瘢痕颜色更佳（4.2±0.8 vs. 3.4±0.5；p = 0.05）、质地更好（4.4±0.5 vs. 3.2±0.8；p = 0.03）、厚度更理想（4.0±0.7 vs. 3.0±1.0；p = 0.04）。在五例病例中，不知情的评估者有四例更倾向于臭氧油治疗的瘢痕。
与传统护理相比，臭氧油显著改善了伤口愈合效果，减轻了疼痛和瘙痒，改善了瘢痕美观度。这些发现支持通过更大规模的随机试验进行进一步研究。鉴于其成本低且使用方便，在农村整形外科环境中，当术后瘢痕管理资源有限时，臭氧油可能是一种有价值的辅助手段。
