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关节镜下基质相关自体软骨细胞植入治疗胫骨局灶性缺损

Arthroscopic Matrix-Associated Autologous Chondrocyte Implantation for Focal Tibial Defects.

作者信息

Franco Domenico, Leite Chilan B G, Schmidt Sebastian, Sherman Nathan, Protzuk Omar, Lattermann Christian

机构信息

Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.

Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.

出版信息

Arthrosc Tech. 2025 Apr 10;14(6):103545. doi: 10.1016/j.eats.2025.103545. eCollection 2025 Jun.

Abstract

Damage to the articular cartilage of the tibial plateau presents significant challenges, resulting in pain, functional impairment, and progressive joint degeneration that can lead to severe osteoarthritis. Traditional open surgeries, although effective, are associated with substantial tissue disruption, prolonged recovery, and risks of complications. Here, we present an arthroscopic technique for matrix-associated autologous chondrocyte implantation tailored to address focal tibial cartilage defects. This technique integrates meticulous arthroscopic preparation of the defect site and precise implantation of the matrix-associated autologous chondrocyte implantation membrane. The postoperative protocol emphasizes gradual weight-bearing and progressive functional recovery, enabling a safe return to daily activities and sports.

摘要

胫骨平台关节软骨损伤带来了重大挑战,会导致疼痛、功能障碍以及关节进行性退变,进而引发严重的骨关节炎。传统的开放手术虽然有效,但会造成大量组织破坏、恢复时间延长以及并发症风险。在此,我们介绍一种针对局灶性胫骨软骨缺损的关节镜下基质相关自体软骨细胞植入技术。该技术整合了对缺损部位细致的关节镜下准备以及基质相关自体软骨细胞植入膜的精确植入。术后方案强调逐步负重和渐进性功能恢复,使患者能够安全地恢复日常活动和运动。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba2b/12255457/9a8f25fc1011/gr1.jpg

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