Gökmen Karakaya Melek, Gezer Bahdişen, Menzek Abdullah, Gündoğdu Aytaç Özlem
Laboratory Technology Program, Department of Chemistry and Chemical Processing Technologies, Banaz Vocational School, Uşak University, Uşak, Turkiye.
Electrical Electronics Program, Department of Electrical Electronics Engineering, Faculty of Engineering and Natural Sciences, Uşak University, Uşak, Turkiye.
Turk J Chem. 2025 Mar 12;49(3):279-292. doi: 10.55730/1300-0527.3729. eCollection 2025.
Climbazole (CBZ) is an antifungal active pharmaceutical ingredient often used in antidandruff products. In this study, the ketone group in the racemic CBZ molecule was reduced to synthesize CBZ-alcohol, named 1-(4-chlorophenoxy)-1-(1-imidazol-1-yl)-3,3-dimethylbutan-2-ol, and the optimum adsorption conditions were investigated for removing iron(II) (Fe) ions from wastewater by adsorption from aqueous solutions using the economical and environmentally friendly ultrasonic method. The parameters and levels used in the study were designed using response surface methodology and model equations were derived to optimize the results. The independent variables selected were the initial pH (1, 3, and 5), adsorption time (30, 45, and 60 min), adsorption temperature (40, 60, and 80 °C), and Fe ions consumption percentage from the wastewater. Experiments were conducted on a real wastewater sample taken from the Uşak Organized Industrial Zone. Conditions that maximize each dependent variable were specified separately and verification experiments were conducted under these conditions. Maximum Fe ion consumption was 91.83%. The R value of the model was 0.9598. The findings demonstrate that CBZ-alcohol was effective as an adsorbent in Fe ion removal from aqueous solution.
克霉唑（CBZ）是一种常用于去屑产品的抗真菌活性药物成分。在本研究中，将外消旋CBZ分子中的酮基还原以合成CBZ-醇，即1-(4-氯苯氧基)-1-(1-咪唑-1-基)-3,3-二甲基丁烷-2-醇，并采用经济环保的超声法研究了从水溶液中吸附去除废水中铁（II）（Fe）离子的最佳吸附条件。使用响应面法设计了研究中使用的参数和水平，并推导了模型方程以优化结果。选择的自变量为初始pH（1、3和5）、吸附时间（30、45和60分钟）、吸附温度（40、60和80°C）以及废水中Fe离子的消耗百分比。对取自于斯阿克有组织工业区的实际废水样本进行了实验。分别指定了使每个因变量最大化的条件，并在这些条件下进行了验证实验。最大Fe离子消耗量为91.83%。该模型的R值为0.9598。研究结果表明，CBZ-醇作为一种吸附剂在从水溶液中去除Fe离子方面是有效的。
