Wang Yeqing, Gao Guofang, Zhu Zhongxin
Department of Scientific Research and Education, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, China.
Department of Pharmacy, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, China.
Geriatr Orthop Surg Rehabil. 2025 Jul 11;16:21514593251360384. doi: 10.1177/21514593251360384. eCollection 2025.
Osteoarthritis (OA) is a prevalent chronic joint disease affecting approximately 7% of the global population, with increasing significance in aging populations. Sarcopenia and obesity, two interconnected age-associated conditions, have potential pathogenic roles in OA development, yet their precise interactions remain incompletely understood.
A cross-sectional analysis was conducted using National Health and Nutrition Examination Survey (NHANES) data from 1999-2006, focusing on 2309 participants aged 65 years and older. Sarcopenia and obesity were assessed via dual-energy X-ray absorptiometry-derived body composition measures, and OA status was determined through self-reported physician diagnoses. Multiple logistic regression models were employed to investigate the correlations between sarcopenia, obesity status, and the prevalence of OA.
Sarcopenia was positively associated with OA, with an adjusted OR of 1.38 (95% CI: 1.07-1.79). Obesity demonstrated a consistent positive correlation with OA (adjusted OR: 1.31, 95% CI: 1.03-1.65). Subgroup analyses revealed nuanced associations, particularly among specific demographic groups such as non-Hispanic Black individuals and those with comorbidities like hypertension and diabetes.
The study reveals complex interrelationships between sarcopenia, obesity, and OA prevalence in older adults. The findings underscore the importance of body composition in joint health and suggest the need for targeted interventions considering demographic and clinical variations.
骨关节炎（OA）是一种常见的慢性关节疾病，影响着全球约7%的人口，在老龄化人群中的重要性日益增加。肌肉减少症和肥胖症是两种相互关联的与年龄相关的病症，在OA的发展中具有潜在的致病作用，但其确切的相互作用仍未完全了解。
使用1999 - 2006年美国国家健康与营养检查调查（NHANES）的数据进行横断面分析，重点关注2309名65岁及以上的参与者。通过双能X线吸收法得出的身体成分测量来评估肌肉减少症和肥胖症，并通过自我报告的医生诊断来确定OA状态。采用多元逻辑回归模型来研究肌肉减少症、肥胖状态与OA患病率之间的相关性。
肌肉减少症与OA呈正相关，调整后的比值比（OR）为1.38（95%置信区间：1.07 - 1.79）。肥胖症与OA也呈现出一致的正相关（调整后的OR：1.31，95%置信区间：1.03 - 1.65）。亚组分析揭示了细微的关联，特别是在非西班牙裔黑人个体以及患有高血压和糖尿病等合并症的特定人群中。
该研究揭示了老年人中肌肉减少症、肥胖症与OA患病率之间的复杂相互关系。研究结果强调了身体成分在关节健康中的重要性，并表明需要考虑人口统计学和临床差异进行有针对性的干预。
