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新冠病毒病与抑郁症发生的关联

Association of Covid-19 With the Occurrence of a Depressive Disorder.

作者信息

Bijedic Danijel, Becirovic Elvir, Petrovic Jasminka, Jahic Humera Porobic, Trnacevic Alma, Zigic Azra

机构信息

Clinic for Infectious Diseases, Department for Hepatology, University Clinical Center Tuzla, Tuzla, BiH.

出版信息

Med Arch. 2025;79(3):211-214. doi: 10.5455/medarh.2025.79.211-214.

Abstract

BACKGROUND

Depressive disorder is characterized by a persistent low mood (sadness, irritability, or emptiness) or a loss of pleasure, accompanied by other cognitive, behavioral, or neurovegetative symptoms that significantly impair a person's ability to function. Anxiety and fear-related disorders are marked by excessive anxiety and fear, which lead to behavioral disturbances and cause significant distress or impair personal, family, social, educational, occupational, or other key areas of functioning.

OBJECTIVE

The aim of this study was to analyze whether there are differences in the development of depressive symptoms between COVID-19 patients and patients with symptoms of the flu or common cold.

METHODS

This is a prospective study that included sixty participants: thirty with COVID-19 and thirty without COVID-19. Data were collected from the ambulatory observational records of participants, documenting their symptoms. We analyzed the relationship between variables such as age, sex, education, and the level of potential depression. The participants were divided into two groups: one consisting of individuals with COVID-19 and the other of individuals without COVID-19. All participants were male and female, aged between 40 and 65 years, and had no previous history of depressive disorder. The first group consisted of patients with COVID-19 who were treated at home but were examined at our outpatient clinic and subsequently sent home.

RESULTS

Statistical data processing was performed using the Excel program and the R statistical data processing program. Percentages are calculated in relation to 30 respondents in each group.There was no statistically significant correlation between the level of education in Group 1 and the development of depression(Spearman ro=0.007, P=0.972). In Group 1 (Covid ) there is a statistically significant correlation between the age of the subjects and the development of depression (Spearman ro=0.44, P=0.015). A positive value of the Spearman correlation coefficient means that the score increases with the age of the respondent. Three questions with the highest score in group 1 were: Question 2=71, Questions 15 and 16=66, Question 14=65; three questions with the highest score in group 2 were: Question 2=74, Question 1 =50, Question 18=46.

CONCLUSION

COVID-19 can contribute to the development of depression. In our study, 16.7% of patients with COVID-19 showed signs of depression, with 10% experiencing mild depression and 6.7% experiencing moderate depression. Patients in the first group, particularly those of older age, were more likely to develop mild or moderate depression associated with COVID-19. Additionally, no statistically significant correlation was found between the level of education in Group 1 and the development of depression.

摘要

背景

抑郁症的特征是持续的情绪低落(悲伤、易怒或空虚)或丧失愉悦感,并伴有其他认知、行为或神经植物性症状,这些症状会严重损害一个人的功能能力。焦虑和恐惧相关障碍的特点是过度焦虑和恐惧,这会导致行为紊乱,并造成严重困扰或损害个人、家庭、社会、教育、职业或其他关键功能领域。

目的

本研究的目的是分析新冠病毒病患者与流感或普通感冒症状患者在抑郁症状发展方面是否存在差异。

方法

这是一项前瞻性研究,包括60名参与者:30名新冠病毒病患者和30名非新冠病毒病患者。从参与者的门诊观察记录中收集数据,记录他们的症状。我们分析了年龄、性别、教育程度和潜在抑郁水平等变量之间的关系。参与者被分为两组:一组由新冠病毒病患者组成,另一组由非新冠病毒病患者组成。所有参与者均为男性和女性,年龄在40至65岁之间,且既往无抑郁症病史。第一组由在家接受治疗但在我们的门诊接受检查并随后送回家的新冠病毒病患者组成。

结果

使用Excel程序和R统计数据处理程序进行统计数据处理。百分比是相对于每组30名受访者计算的。第一组的教育程度与抑郁症的发展之间没有统计学上的显著相关性(斯皮尔曼等级相关系数ro = 0.007,P = 0.972)。在第一组(新冠病毒病组)中,受试者的年龄与抑郁症的发展之间存在统计学上的显著相关性(斯皮尔曼等级相关系数ro = 0.44,P = 0.015)。斯皮尔曼相关系数的正值意味着得分随着受访者年龄的增加而增加。第一组中得分最高的三个问题是:问题2 = 71,问题15和16 = 66,问题14 = 65;第二组中得分最高的三个问题是:问题2 = 74,问题1 = 50,问题18 = 46。

结论

新冠病毒病可能导致抑郁症的发展。在我们的研究中,16.7%的新冠病毒病患者表现出抑郁迹象,其中10%经历轻度抑郁,6.7%经历中度抑郁。第一组患者,特别是年龄较大的患者,更有可能发展为与新冠病毒病相关的轻度或中度抑郁。此外,第一组的教育程度与抑郁症的发展之间未发现统计学上的显著相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8025/12253576/be2f3d06082e/medarch-79-211-g001.jpg

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