Dung Bui The, Dan Pham Ngoc, Nhut Nguyen Minh
Department of Cardiology, University Medical Center HCMC, Ho Chi Minh City, Vietnam.
Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Med Arch. 2025;79(3):190-193. doi: 10.5455/medarh.2025.79.190-193.
Infective endocarditis (IE) is a severe disease associated with high in-hospital mortality. Prognostic factors and the independent role of cardiac surgery remain unclear in clinical practice in Vietnam.
To identify factors associated with in-hospital mortality in IE patients and evaluate the independent role of cardiac surgery.
This retrospective descriptive-analytical study included 129 patients diagnosed with IE at the University Medical Center Ho Chi Minh City from January 2019 to April 2024. Clinical, laboratory, treatment, and outcome data were collected. Logistic regression analyses were performed to identify mortality predictors.
The in-hospital mortality rate was 16.3%. Univariate analysis identified hepatic failure, septic shock, ventilator-associated pneumonia, disseminated intravascular coagulation (DIC), and absence of surgery as associated factors. In multivariate analysis, septic shock (OR = 22.0; 95% CI: 7.1-68.5) and not undergoing cardiac surgery (OR = 0.07; 95% CI: 0.01-0.43) were independent predictors.
In-hospital mortality in IE remains high. Early identification of high-risk patients and improved access to indicated cardiac surgery may enhance prognosi.
感染性心内膜炎（IE）是一种严重疾病，与较高的院内死亡率相关。在越南的临床实践中，预后因素以及心脏手术的独立作用仍不明确。
确定IE患者院内死亡的相关因素，并评估心脏手术的独立作用。
这项回顾性描述性分析研究纳入了2019年1月至2024年4月在胡志明市大学医学中心诊断为IE的129例患者。收集了临床、实验室、治疗和结局数据。进行逻辑回归分析以确定死亡预测因素。
院内死亡率为16.3%。单因素分析确定肝衰竭、感染性休克、呼吸机相关性肺炎、弥散性血管内凝血（DIC）和未进行手术为相关因素。多因素分析中，感染性休克（OR = 22.0；95%CI：7.1 - 68.5）和未接受心脏手术（OR = 0.07；95%CI：0.01 - 0.43）是独立预测因素。
IE患者的院内死亡率仍然很高。早期识别高危患者并改善接受心脏手术的机会可能会改善预后。
