Cai Shijie, Zhu Jiahua, Xu Zhiye, Chen Wenqin, Tao Yue, Huang Taihong, Wang Sen
Department of Clinical Laboratory Medicine, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China.
Department of Clinical Laboratory Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Front Microbiol. 2025 Jun 27;16:1604243. doi: 10.3389/fmicb.2025.1604243. eCollection 2025.
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by Dabie bandavirus (DBV), clinically characterized by fever, thrombocytopenia, and multiple organ dysfunction. Severe cases are often associated with cytokine storms and exhibit a high mortality rate. Calprotectin (CP), an inflammatory marker mainly expressed in neutrophils and monocytes, has been linked to disease activity and prognosis in various inflammatory conditions. This study aimed to investigate the changes in serum calprotectin (sCP) levels and their clinical relevance in SFTS patients.
Serum calprotectin levels were measured in 60 patients diagnosed with SFTS and compared with those in 60 healthy controls. The association of sCP levels with disease severity, outcome, inflammatory markers, viral load, cytokines, and clinical parameters was analyzed.
sCP levels were significantly elevated in SFTS patients compared to healthy controls. Severe cases and non-survivors had notably higher sCP levels than mild cases and survivors, respectively. sCP levels showed positive correlations with viral load, inflammatory cytokines (e.g., TNF-α, IL-6, IL-8, IL-10), and clinical parameters such as CRP, AST, LDH, and D-dimer. Moreover, increased sCP levels were observed in patients with renal injury, hepatic injury, and neurological symptoms.
The present study suggests that sCP levels are closely related to disease severity and prognosis, highlighting its potential as a biomarker for diagnosing and prognostic assessment in SFTS patients.
发热伴血小板减少综合征（SFTS）是由大别病毒（DBV）引起的一种新发传染病，临床特征为发热、血小板减少及多器官功能障碍。重症病例常伴有细胞因子风暴，死亡率高。钙卫蛋白（CP）是一种主要在中性粒细胞和单核细胞中表达的炎症标志物，与多种炎症性疾病的疾病活动度及预后相关。本研究旨在探讨SFTS患者血清钙卫蛋白（sCP）水平的变化及其临床意义。
检测60例确诊为SFTS患者的血清钙卫蛋白水平，并与60例健康对照者进行比较。分析sCP水平与疾病严重程度、预后、炎症标志物、病毒载量、细胞因子及临床参数的相关性。
与健康对照相比，SFTS患者的sCP水平显著升高。重症病例和非幸存者的sCP水平分别明显高于轻症病例和幸存者。sCP水平与病毒载量、炎症细胞因子（如TNF-α、IL-6、IL-8、IL-10）以及CRP、AST、LDH和D-二聚体等临床参数呈正相关。此外，在有肾损伤、肝损伤及神经症状的患者中观察到sCP水平升高。
本研究表明，sCP水平与疾病严重程度及预后密切相关，凸显了其作为SFTS患者诊断及预后评估生物标志物的潜力。
