Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.
Department of Postgraduate Medical Education, Japanese Red Cross Society Himeji Hospital, Himeji 670-8540, Japan.
Int J Environ Res Public Health. 2022 Feb 17;19(4):2271. doi: 10.3390/ijerph19042271.
Severe fever with thrombocytopenia syndrome (SFTS) is an infection mediated by ticks and has been reported to have a high mortality rate in Japan. At our hospital, we reported three cases of SFTS with relatively positive outcomes. We reviewed reports of SFTS cases in Japan to clarify the current state of the disease in Japan, the treatment provided, and its outcome. The Ichushi Web was searched for literature using the following terms as keywords: "SFTS" or "severe fever with thrombocytopenia syndrome". Overall, 174 cases were collected and reviewed. The mean age of patients was 70.69 years old, and the mortality rate was 35%. The dead group was significantly older ( < 0.001) than the alive group, had a significantly shorter period from symptom onset to hospital admission, and experienced significantly more hemorrhage-related and neurological symptoms. Further, the most frequently provided treatment methods were adrenocorticosteroids, antibiotics, and conservative treatment. The low recognition rate of SFTS in Japan might lead to a misdiagnosis or delay in diagnosis and treatment, especially in mild to moderate cases. Medical professionals and citizens who live in areas inhabited by ticks need to be informed about SFTS to appropriately diagnose and manage SFTS cases in Japan in the future.
严重发热伴血小板减少综合征（SFTS）是一种由蜱传播的感染，在日本的死亡率很高。在我们医院，我们报告了三例 SFTS 病例，结果相对较好。我们回顾了日本 SFTS 病例的报告，以阐明日本目前的疾病状况、提供的治疗方法及其结果。我们在 Ichushi Web 上使用以下关键词搜索文献：“SFTS”或“严重发热伴血小板减少综合征”。共收集和回顾了 174 例病例。患者的平均年龄为 70.69 岁，死亡率为 35%。死亡组明显比存活组年龄更大（<0.001），从症状出现到住院的时间明显更短，并且经历了更多与出血和神经系统相关的症状。此外，最常提供的治疗方法是皮质类固醇、抗生素和保守治疗。日本对 SFTS 的低认识率可能导致误诊或治疗延误，特别是在轻度和中度病例中。生活在蜱虫出没地区的医疗专业人员和市民需要了解 SFTS，以便在未来在日本适当诊断和管理 SFTS 病例。
