Takeichi M
Folia Psychiatr Neurol Jpn. 1985;39(2):185-91. doi: 10.1111/j.1440-1819.1985.tb02902.x.
The effect of chronic administration of chlorpromazine (CPZ) on the striatal synaptic vesicles was quantitatively investigated with an electron microscope. Six rats, three controls and three experimentals, which received 20 mg/kg b.wt. of CPZ daily for 15 months, were sacrificed and a total of 300 axo-dendritic spine synapses (50 synapses per animal) were randomly taken and divided into three zones with a width of 160-467 nm on electron micrographs (final magnification 60,000). The first zone was adjacent to the presynaptic membrane in the region of the synaptic cleft. The second and third were farther away from the first zone. In these zones we measured the vesicle density, vesicle size and vesicle elongation ratio (the shortest diameter/the longest diameter) with the following results: In both the CPZ-administered rats and the controls the vesicle number per unit area of axoplasm (vesicle density) was smaller in Zone III than in Zones I and II, while those in the latter two zones did not differ from each other. However, there was no significant difference in the vesicle number in any zone between the control and experimental animals. The vesicles in every zone were significantly larger in the CPZ-administered animals than in the controls. There were no conclusive findings on the vesicle elongation ratio (vesicle shape).
用电子显微镜定量研究了长期给予氯丙嗪（CPZ）对纹状体突触小泡的影响。选取6只大鼠，其中3只为对照组，3只为实验组，实验组大鼠每日按20mg/kg体重给予CPZ，持续15个月。处死大鼠后，在电子显微镜照片（最终放大倍数60,000）上随机选取总共300个轴突-树突棘突触（每只动物50个突触），并将其分为三个区域，宽度为160 - 467nm。第一个区域紧邻突触间隙处的突触前膜。第二和第三个区域离第一个区域较远。在这些区域中，我们测量了小泡密度、小泡大小和小泡伸长率（最短直径/最长直径），结果如下：在给予CPZ的大鼠和对照组中，轴浆单位面积的小泡数量（小泡密度）在区域III中比在区域I和II中少，而后两个区域之间没有差异。然而，对照组和实验组动物在任何区域的小泡数量上没有显著差异。给予CPZ的动物每个区域的小泡都比对照组的明显更大。关于小泡伸长率（小泡形状）没有确凿的发现。
