十二指肠内应用亚硫酸盐后大鼠血浆中亚硫酸盐和S-磺酸盐的出现情况。

Appearance of sulphite and S-sulphonates in the plasma of rats after intraduodenal sulphite application.

作者信息

Wever J

出版信息

Food Chem Toxicol. 1985 Oct;23(10):895-8. doi: 10.1016/0278-6915(85)90104-8.

Abstract

Before intraduodenal administration of sodium sulphite solutions to anaesthetized rats, the portal vein and the vena cava were cannulated for blood sampling. Examination of the plasma showed that S-sulphonates were present in both pre- and post-hepatic blood, whereas free sulphite was detectable in the portal blood only. It can be concluded that sulphite is absorbed and quickly metabolized, either by oxidation or by the formation of S-sulphonates.

摘要

在向麻醉大鼠十二指肠内注射亚硫酸钠溶液之前，将门静脉和腔静脉插管用于采血。血浆检查表明，肝前和肝后血液中均存在S-磺酸盐，而仅在门静脉血中可检测到游离亚硫酸盐。可以得出结论，亚硫酸盐可被吸收并迅速代谢，要么通过氧化，要么通过形成S-磺酸盐。