Zhang Helin, Zhang Xingxing, Du Yuelin, Xiong Wei, Zhang Xiaojun, Zhang Biao, Shang Panfeng
The Second Hospital and Clinical Medical School, Lanzhou University, No. 82 Cui Ying Gate, Cheng Guan District, Lanzhou, 730000, Gansu, China.
Key Laboratory of Urological Diseases in Gansu Province, Lanzhou, China.
Clin Transl Oncol. 2025 Jul 14. doi: 10.1007/s12094-025-03964-4.
Emerging evidence highlights diverse roles of FSTL1 across various malignancies, though its biological significance in bladder carcinogenesis remains unexplored.
This study systematically interrogated FSTL1 using multidimensional bioinformatics approaches-including tumor microenvironment characterization, survival pattern evaluation, and differential expression profiling-through multiple bladder cancer datasets from TCGA and GEO repositories, with subsequent experimental validation employing in vitro cellular models.
Our findings demonstrate that FSTL1 exhibits significant overexpression in bladder tumors, promotes cancer cell motility through pro-migratory mechanisms, and potentially modulates key components of the tumor microenvironment.
FSTL1 might be a therapeutic target or biomarker for the advancement of bladder cancer.
新出现的证据凸显了FSTL1在各种恶性肿瘤中的多种作用，但其在膀胱癌发生中的生物学意义仍未得到探索。
本研究通过来自TCGA和GEO数据库的多个膀胱癌数据集，运用多维生物信息学方法——包括肿瘤微环境特征分析、生存模式评估和差异表达谱分析——对FSTL1进行了系统研究，并随后采用体外细胞模型进行了实验验证。
我们的研究结果表明，FSTL1在膀胱肿瘤中显著过表达，通过促迁移机制促进癌细胞迁移，并可能调节肿瘤微环境的关键成分。
FSTL1可能是膀胱癌进展的治疗靶点或生物标志物。
