Starnini Jean-Guillaume, Natalello Giulio, Nigroli Federico, Diana Chiara, Bargagli Elena, Melani Andrea Sisto
Clinica Malattie Apparato Respiratorio, Azienda Ospedaliera Universitaria Senese, Policlinico S. Maria Alle Scotte, UOC Malattie Dell'apparato respiratorio, AOUS Le Scotte, Siena, Italy.
Pulm Ther. 2025 Jul 14. doi: 10.1007/s41030-025-00305-2.
The evidence that tobacco cigarettes are harmful to the health of smokers led to the introduction of electronic nicotine delivery systems (ENDS) as a safer alternative. ENDS, which include electronic cigarettes (e-cigs) and heated tobacco products (battery-operated devices that heat a liquid and produce an aerosol), are portable, cheap, easy-to-use, self-powered devices, and resemble tobacco cigarettes. After an overview of the toxicological, clinical, and epidemiological implications associated with the increasingly widespread use of ENDS, this narrative paper evaluates their role as a smoking cessation aid. Randomized controlled trials show that e-cigs can help in achieving cigarette smoking cessation, but their role in real life is still debated. There is no clear association in current smokers between the prevalence of e-cig use and overall quit rates. Although ENDS are not Food and Drug Administration (FDA)- and European Medicines Agency (EMA)-approved for quitting, they are one of the most widely utilized pharmacological support devices for smoking cessation. Physicians should ask for ENDS use and amount at each visit, be able to advise on how to manage ENDS as an aid for quitting, encourage vapers not to continue their use indefinitely, and explain how to stop ENDS.
有证据表明，烟草香烟对吸烟者健康有害，这促使电子尼古丁传送系统（ENDS）作为一种更安全的替代品被引入。ENDS包括电子烟（e-cigs）和加热烟草产品（通过电池供电加热液体并产生气溶胶的装置），是便携、便宜、易于使用的自供电设备，且类似烟草香烟。在概述了与ENDS日益广泛使用相关的毒理学、临床和流行病学影响之后，本篇叙述性论文评估了它们作为戒烟辅助手段的作用。随机对照试验表明，电子烟有助于实现戒烟，但它们在现实生活中的作用仍存在争议。目前吸烟者中电子烟使用的流行率与总体戒烟率之间没有明确关联。尽管ENDS未获美国食品药品监督管理局（FDA）和欧洲药品管理局（EMA）批准用于戒烟，但它们是最广泛使用的戒烟药理支持设备之一。医生每次问诊时都应询问ENDS的使用情况和用量，能够就如何将ENDS作为戒烟辅助手段提供建议，鼓励电子烟使用者不要无限期持续使用，并解释如何停用ENDS。
