Tsuneyoshi M, Daimaru Y, Hashimoto H, Enjoji M
Hum Pathol. 1985 Dec;16(12):1235-42. doi: 10.1016/s0046-8177(85)80036-8.
Five round cell neoplasms of the soft parts that histologically resembled malignant rhabdoid tumors of the kidney were studied. The tumors were composed mainly of poorly differentiated round or, sometimes, polygonal cells, with a minority of elongated cells; the cytoplasm of many of the cells contained filament-laden acidophilic inclusions. Ultrastructurally, the intracytoplasmic structures were seen to consist of aggregates of 10-nm intermediate filaments, and immunohistochemical staining revealed the presence of cytokeratin and vimentin. All five patients with this tumor had an aggressive clinical course; three of the patients died shortly after the initial diagnosis. As this tumor does not seem to be linked to any known entity, it is referred to as malignant rhabdoid tumor of the soft parts and could be a heterogeneous entity.
对5例软组织圆形细胞瘤进行了研究，其组织学表现类似于肾恶性横纹肌样瘤。肿瘤主要由低分化的圆形细胞组成，有时也有少数多边形细胞，还有少数细长细胞；许多细胞的细胞质中含有充满细丝的嗜酸性包涵体。超微结构显示，胞质内结构由10纳米中间丝聚集而成，免疫组化染色显示有细胞角蛋白和波形蛋白。这5例肿瘤患者的临床病程均呈侵袭性；3例患者在初诊后不久死亡。由于该肿瘤似乎与任何已知实体均无关联，故称为软组织恶性横纹肌样瘤，可能是一种异质性实体。
