Lorian V
Pathol Biol (Paris). 1977 May;25(5):291-8.
Experiments with subinhibitory concentrations of antibiotics revealed certain effects that had not been observed at higher concentrations. Two different effects are described: morphological changer and inhibition of growth. The expression minimum antibiotic concentration (MAC) has been shown to be of both theoretical and practical value. It has served to make plain the differences between the effects of various antibodies that were not observed at the MIC. The ratio MAC/MIC could be be of importance to characterize the effect of antibiotics.
用亚抑制浓度的抗生素进行的实验揭示了在较高浓度下未观察到的某些效应。描述了两种不同的效应:形态变化和生长抑制。最低抗生素浓度(MAC)的表达已显示出理论和实际价值。它有助于阐明在最低抑菌浓度(MIC)下未观察到的各种抗体效应之间的差异。MAC/MIC比值对于表征抗生素的效应可能很重要。