RU 28965（罗红霉素）与人类中性粒细胞在体外杀菌活性方面的协同作用。
Synergy between RU 28965 (roxithromycin) and human neutrophils for bactericidal activity in vitro.
作者信息
Labro M T, Amit N, Babin-Chevaye C, Hakim J
出版信息
Antimicrob Agents Chemother. 1986 Jul;30(1):137-42. doi: 10.1128/AAC.30.1.137.
Abstract
The in vitro effects of RU 28965 (roxithromycin), a new semisynthetic macrolide, on human neutrophil activity were compared with those of erythromycin. RU 28965, at a concentration as low as 0.1 microgram/ml, significantly enhanced the phagocytosis and killing of Staphylococcus aureus by neutrophils. Erythromycin displayed a less stimulating effect in a dose-dependent manner. Phagocytosis of Klebsiella pneumoniae was also increased after incubation of neutrophils with RU 28965, but killing was not altered. Neutrophil chemotaxis, myeloperoxidase activity, and O2 consumption were unchanged in the presence of RU 28965.
摘要
将新型半合成大环内酯类药物RU 28965（罗红霉素）与红霉素对人中性粒细胞活性的体外作用进行了比较。RU 28965在低至0.1微克/毫升的浓度下，能显著增强中性粒细胞对金黄色葡萄球菌的吞噬作用和杀伤能力。红霉素则呈剂量依赖性地表现出较小的刺激作用。中性粒细胞与RU 28965孵育后，对肺炎克雷伯菌的吞噬作用也增强，但杀伤能力未改变。在RU 28965存在的情况下，中性粒细胞趋化性、髓过氧化物酶活性和氧气消耗均未改变。
相似文献
1
Synergy between RU 28965 (roxithromycin) and human neutrophils for bactericidal activity in vitro.RU 28965（罗红霉素）与人类中性粒细胞在体外杀菌活性方面的协同作用。
Antimicrob Agents Chemother. 1986 Jul;30(1):137-42. doi: 10.1128/AAC.30.1.137.
2
[Interaction of roxithromycin with human polymorphonuclear neutrophils in vitro and ex vivo].[罗红霉素在体外和体内与人类多形核中性粒细胞的相互作用]
Pathol Biol (Paris). 1988 Jun;36(5 Pt 2):711-4.
3
4
In vitro activity of flurithromycin, a novel macrolide antibiotic.
Chemioterapia. 1986 Jun;5(3):177-84.
5
Effects of cefotaxime and cefodizime on human granulocyte functions in vitro.
J Antimicrob Chemother. 1986 Aug;18(2):233-7. doi: 10.1093/jac/18.2.233.
6
[Bactericidal synergy of josamycin and human polynuclear neutrophils in vitro].[交沙霉素与人类多核中性粒细胞在体外的杀菌协同作用]
Pathol Biol (Paris). 1989 May;37(5):329-34.
7
Interaction of ceftriaxone with human polymorphonuclear neutrophil function.头孢曲松与人类多形核中性粒细胞功能的相互作用。
J Antimicrob Chemother. 1987 Dec;20(6):849-55. doi: 10.1093/jac/20.6.849.
8
Synergistic interaction of josamycin with human neutrophils bactericidal function in vitro.交沙霉素与人中性粒细胞体外杀菌功能的协同相互作用。
J Antimicrob Chemother. 1989 Nov;24(5):731-40. doi: 10.1093/jac/24.5.731.
9
An in-vitro comparison of the intraphagocytic bioactivity of erythromycin and roxithromycin.
J Antimicrob Chemother. 1987 Nov;20 Suppl B:57-68. doi: 10.1093/jac/20.suppl_b.57.
10
Comparison of the in-vitro effect of several macrolides on the oxidative burst of human neutrophils.
J Antimicrob Chemother. 1989 Oct;24(4):561-72. doi: 10.1093/jac/24.4.561.
引用本文的文献
1
Effect of telithromycin (HMR 3647) on polymorphonuclear neutrophil killing of Staphylococcus aureus in comparison with roxithromycin.与罗红霉素相比，泰利霉素（HMR 3647）对金黄色葡萄球菌多形核中性粒细胞杀伤作用的影响。
Antimicrob Agents Chemother. 2002 May;46(5):1364-74. doi: 10.1128/AAC.46.5.1364-1374.2002.
2
Clarithromycin clinical pharmacokinetics.克拉霉素的临床药代动力学。
Clin Pharmacokinet. 1993 Sep;25(3):189-204. doi: 10.2165/00003088-199325030-00003.
3
Effect of roxithromycin on acute toxoplasmosis in mice.罗红霉素对小鼠急性弓形虫病的影响。
Antimicrob Agents Chemother. 1987 Jul;31(7):1147-9. doi: 10.1128/AAC.31.7.1147.
4
Unpredictable influence of human serum on antimicrobial activity of erythromycin and three oxime ether macrolides.
Eur J Clin Microbiol. 1987 Feb;6(1):81-2. doi: 10.1007/BF02097206.
5
Effects of amodiaquine, chloroquine, and mefloquine on human polymorphonuclear neutrophil function in vitro.阿莫地喹、氯喹和甲氟喹对人多形核中性粒细胞体外功能的影响。
Antimicrob Agents Chemother. 1988 Aug;32(8):1124-30. doi: 10.1128/AAC.32.8.1124.
6
In vitro effects of four macrolides (roxithromycin, spiramycin, azithromycin [CP-62,993], and A-56268) on Toxoplasma gondii.四种大环内酯类药物（罗红霉素、螺旋霉素、阿奇霉素[CP-62,993]和A-56268）对刚地弓形虫的体外作用。
Antimicrob Agents Chemother. 1988 Apr;32(4):524-9. doi: 10.1128/AAC.32.4.524.
7
In vitro effects of antimicrobial agents on Mycobacterium leprae in mouse peritoneal macrophages.抗菌剂对小鼠腹腔巨噬细胞中麻风分枝杆菌的体外作用。
Antimicrob Agents Chemother. 1989 May;33(5):657-62. doi: 10.1128/AAC.33.5.657.
8
Roxithromycin. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy.罗红霉素：抗菌活性、药代动力学特性及临床疗效综述
Drugs. 1989 Jan;37(1):8-41. doi: 10.2165/00003495-198937010-00002.
9
Quinine uptake by human polymorphonuclear neutrophils.人多形核中性粒细胞对奎宁的摄取。
Antimicrob Agents Chemother. 1991 Jul;35(7):1474-8. doi: 10.1128/AAC.35.7.1474.
10
Effects of anti-infectious agents on polymorphonuclear neutrophils.抗感染药物对多形核中性粒细胞的作用。
Eur J Clin Microbiol Infect Dis. 1991 Feb;10(2):124-31. doi: 10.1007/BF01964424.
本文引用的文献
1
Inhibition of PMN leukocytes chemotaxis by thalidomide.沙利度胺对中性粒细胞趋化性的抑制作用。
Arch Dermatol Res. 1980;269(3):275-80. doi: 10.1007/BF00406421.
2
Further studies on erythromycin effects on cellular immune functions in vitro and in vivo. Enhancement of neutrophil motility by erythromycin combined with ascorbate or thiamine.关于红霉素对体外和体内细胞免疫功能影响的进一步研究。红霉素与抗坏血酸或硫胺素联合使用可增强中性粒细胞的运动能力。
J Antimicrob Chemother. 1982 Nov;10(5):409-17. doi: 10.1093/jac/10.5.409.
3
Killing of gram-negative bacteria by polymorphonuclear leukocytes: role of an O2-independent bactericidal system.多形核白细胞对革兰氏阴性菌的杀伤作用：一种不依赖氧气的杀菌系统的作用。
J Clin Invest. 1982 Apr;69(4):959-70. doi: 10.1172/jci110535.
4
Kinetics of phagocytosis and intracellular killing of Staphylococcus aureus and Escherichia coli by human monocytes.人单核细胞对金黄色葡萄球菌和大肠杆菌的吞噬作用及细胞内杀伤动力学
Scand J Immunol. 1981;13(2):159-74. doi: 10.1111/j.1365-3083.1981.tb00122.x.
5
A radiometric assay for the combined measurement of phagocytosis and intracellular killing of Candida albicans.一种用于联合测量白色念珠菌吞噬作用和细胞内杀伤的放射性测定法。
Clin Exp Immunol. 1980 Nov;42(2):226-33.
6
Chemokinetic activity of N-formyl-methionyl-leucyl-phenylalanine on human neutrophils, and its modulation by phenylbutazone.N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸对人中性粒细胞的趋化活性及其受保泰松的调节作用。
Biochem Pharmacol. 1982 Oct 1;31(19):3071-6. doi: 10.1016/0006-2952(82)90082-x.
7
Effects of antimicrobial and antineoplastic drugs on the phagocytic and microbicidal function of the polymorphonuclear leukocyte.抗菌和抗肿瘤药物对多形核白细胞吞噬及杀菌功能的影响。
Rev Infect Dis. 1982 May-Jun;4(3):683-97. doi: 10.1093/clinids/4.3.683.
8
Potentiation of phagocytosis of pathogenic bacteria by exposure to low concentrations of antibiotics.
J Antimicrob Chemother. 1984 May;13(5):407-9. doi: 10.1093/jac/13.5.407.
9
In vitro comparison of the activity of RU 28965, a new macrolide, with that of erythromycin against aerobic and anaerobic bacteria.新型大环内酯类药物RU 28965与红霉素对需氧菌和厌氧菌活性的体外比较。
Antimicrob Agents Chemother. 1984 Apr;25(4):529-31. doi: 10.1128/AAC.25.4.529.
10
Erythromycin uptake and accumulation by human polymorphonuclear leukocytes and efficacy of erythromycin in killing ingested Legionella pneumophila.红霉素被人多形核白细胞摄取和积累以及红霉素杀灭摄入的嗜肺军团菌的效力。
J Infect Dis. 1984 May;149(5):714-8. doi: 10.1093/infdis/149.5.714.
Zotero 插件