癌症死亡率与衰老：氧化还原疗法是一种选择吗？
Cancer mortality and senescence: Is redox therapy an option?
作者信息
Kuang Shan, Swamynathan Manojit M, Trotman Lloyd C
机构信息
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
出版信息
Genes Dev. 2025 Aug 1;39(15-16):914-916. doi: 10.1101/gad.353129.125.
Abstract
Patient genomics and mouse functional genetics have revealed that senescence is a barrier to metastatic progression of prostate cancer. Many efforts focus on eliminating senescent cells, whereas others aim to elucidate distinct characteristics that set them apart from normal and aging cells. Here, we discuss how exploration of the redox state of senescent cells could help define new markers and pro-oxidant vulnerabilities, drawing analogy to what is known about the redox sensitivity of proliferating cancer cells.
摘要
患者基因组学和小鼠功能遗传学研究表明，衰老细胞是前列腺癌转移进展的一个障碍。许多研究致力于清除衰老细胞，而另一些研究则旨在阐明衰老细胞与正常细胞及衰老细胞不同的独特特征。在此，我们探讨对衰老细胞氧化还原状态的研究如何有助于确定新的标志物和促氧化剂易感性，并将其与已知的增殖癌细胞的氧化还原敏感性进行类比。
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