线粒体年龄类别扩展了组织驻留干细胞的异质性。 - Suppr

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Mitochondrial age-classes expand the heterogeneity of tissue-resident stem cells.

出版信息

Nat Metab. 2025 Jul;7(7):1320-1321. doi: 10.1038/s42255-025-01326-6.

DOI:10.1038/s42255-025-01326-6

PMID:40659912

Abstract

摘要

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Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division.旧过氧化物酶体上的葡萄糖-6-磷酸脱氢酶在不对称细胞分裂后维持上皮干细胞的自我更新。

Nat Commun. 2025 Apr 26;16(1):3932. doi: 10.1038/s41467-025-58752-z.

Metabolic regulation of the hallmarks of stem cell biology.代谢调控干细胞生物学的特征。

Cell Stem Cell. 2024 Feb 1;31(2):161-180. doi: 10.1016/j.stem.2024.01.003.

Alpha-ketoglutarate as a potent regulator for lifespan and healthspan: Evidences and perspectives.α-酮戊二酸作为一种有效的寿命和健康跨度调节剂：证据和展望。

Exp Gerontol. 2023 May;175:112154. doi: 10.1016/j.exger.2023.112154. Epub 2023 Mar 20.

Chemotherapy induced gastrointestinal toxicities.化疗引起的胃肠道毒性。

Adv Cancer Res. 2022;155:131-166. doi: 10.1016/bs.acr.2022.02.007. Epub 2022 Mar 21.

Metabolic determination of cell fate through selective inheritance of mitochondria.通过选择性线粒体遗传来决定细胞命运的代谢途径。

Nat Cell Biol. 2022 Feb;24(2):148-154. doi: 10.1038/s41556-021-00837-0. Epub 2022 Feb 14.

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.单个Lgr5干细胞在体外无需间充质微环境即可构建隐窝-绒毛结构。

Nature. 2009 May 14;459(7244):262-5. doi: 10.1038/nature07935. Epub 2009 Mar 29.

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