Li Ziyuan, Li Xiaona, Yin Wenqiang, Gao Min, Dong Ping, Shi Yongli, Yu Zhaofeng, Feng Zhiqiang, Chen Zhongming
School of Management, Shandong Second Medical University, Weifang, China.
Human Resources Office, Shandong Second Medical University, Weifang, China.
BMC Geriatr. 2025 Jul 14;25(1):523. doi: 10.1186/s12877-025-06184-1.
A significant correlation has been discovered between illness perception and quality of life, but the relationships among illness perception, medication experience, and quality of life remain to be confirmed. Therefore, this study aims to identify the relationship between illness perception and quality of life among Chinese rural elderly patients with hypertension and to analyse the possible mediating role of medication experience between these two aspects.
From September to December 2023, a cross-sectional study was conducted to select rural elderly patients with hypertension by multi-stage stratified random sampling. Data was collected using the brief illness perception questionnaire, the grassroots medication experience scale for patients with chronic diseases and the quality of life scale. Multiple linear regression and Bootstrap method were used to explore the mediating role of medication experience between illness perception and quality of life.
A total of 846 patients met the inclusion criteria. The mean scores of illness perception, medication experience and quality of life at baseline were 4.85 ± 1.04, 4.13 ± 0.52, 4.37 ± 0.37, respectively. The result of Spearman correlation analysis showed that the illness perception was negatively correlated with medication experience (r = -0. 359, P < 0.01) and quality of life (r = -0. 317, P < 0.01), and medication experience was positively correlated with quality of life (r = 0. 511, P < 0.01). The results of mediating effect test indicate that medication experience had a partial mediating effect on the relationship between illness perception and quality of life among rural elderly hypertensive patients, and the mediating effect accounted for 54.21%.
Our findings revealed that illness perception not only directly influenced quality of life among rural elderly hypertensive patients but also indirectly via medication experience. Illness perception is a negative factor affecting the quality of life of rural elderly patients with hypertension, while medication experience is a protective factor. Therefore, medical institutions should strengthen health education to improve their illness perception of hypertension. The pharmaceutical service ability of rural medical institutions should be improved to improve the medication experience of hypertensive patients.
疾病认知与生活质量之间已发现显著相关性，但疾病认知、用药体验和生活质量之间的关系仍有待证实。因此，本研究旨在确定中国农村老年高血压患者的疾病认知与生活质量之间的关系，并分析用药体验在这两个方面之间可能的中介作用。
2023年9月至12月，采用多阶段分层随机抽样进行横断面研究，选取农村老年高血压患者。使用简易疾病认知问卷、基层慢性病患者用药体验量表和生活质量量表收集数据。采用多元线性回归和Bootstrap法探讨用药体验在疾病认知与生活质量之间的中介作用。
共有846例患者符合纳入标准。基线时疾病认知、用药体验和生活质量的平均得分分别为4.85±1.04、4.13±0.52、4.37±0.37。Spearman相关性分析结果显示，疾病认知与用药体验呈负相关（r = -0.359，P < 0.01），与生活质量呈负相关（r = -0.317，P < 0.01），用药体验与生活质量呈正相关（r = 0.511，P < 0.01）。中介效应检验结果表明，用药体验在农村老年高血压患者疾病认知与生活质量的关系中起部分中介作用，中介效应占54.21%。
我们的研究结果表明，疾病认知不仅直接影响农村老年高血压患者的生活质量，还通过用药体验间接影响。疾病认知是影响农村老年高血压患者生活质量的负面因素，而用药体验是保护因素。因此，医疗机构应加强健康教育，以改善他们对高血压的疾病认知。应提高农村医疗机构的药学服务能力，以改善高血压患者的用药体验。
