Huang F, Qiu J, Li Z, Li J, Liao Y T, Huang Z Y, Guo X, Sun X D
Institute of Immunization, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2025 Jul 6;59(7):1047-1053. doi: 10.3760/cma.j.cn112150-20241111-00890.
To analyze the willingness and related factors of pregnant women in Shanghai City to receive influenza vaccines during pregnancy. An online questionnaire survey was conducted among pregnant women who registered in maternal and child health hospitals in 16 districts of Shanghai. The basic information, health status during pregnancy, attitude towards influenza vaccination, and knowledge of influenza and influenza vaccine were collected, and test and multivariate logistic regression analysis were used to analyze the willingness and related factors of pregnant women to receive influenza vaccines during pregnancy. A total of 3 219 valid questionnaires were received, with 10.90% of pregnant women willing to receive influenza vaccination during pregnancy, 57.50% unwilling to receive vaccination and 31.59% holding an uncertain attitude. Among the pregnant women who were willing to receive the vaccine, 82.91% would take the initiative to know the relevant information about the influenza vaccine, and 87.18% understood the transmission routes of the flu. 32.09% believed that pregnant women could receive the influenza vaccination at any stage of pregnancy. Among those who were unwilling and held an uncertain attitude, the proportions of the above three questions were 47.06%, 83.95% and 17.80%, respectively. Among pregnant women who were unwilling to receive vaccination and held an uncertain attitude, the main reason for their vaccine hesitation was the concern about the safety of the vaccine for pregnant women and fetuses during pregnancy. Multivariate logistic regression analysis showed that pregnant women with higher education (=3.278, 95%: 1.678-6.406, =0.001), second trimester (=1.542, 95%: 1.159-2.054, =0.003), third pregnancy (=2.318, 95%: 1.008-5.331, =0.048), and previous influenza vaccination (=1.552, 95%: 1.119-2.152, =0.008) had a higher willingness to receive influenza vaccines during pregnancy. Pregnant women in Shanghai have a relatively low willingness to receive influenza vaccines during pregnancy, mainly due to concerns about vaccine safety.
分析上海市孕妇孕期接种流感疫苗的意愿及相关因素。对上海市16个区妇幼保健院登记在册的孕妇进行在线问卷调查。收集孕妇的基本信息、孕期健康状况、对流感疫苗接种的态度以及流感和流感疫苗知识,采用检验和多因素logistic回归分析孕妇孕期接种流感疫苗的意愿及相关因素。共收到有效问卷3219份,其中10.90%的孕妇愿意在孕期接种流感疫苗,57.50%不愿意接种,31.59%态度不确定。在愿意接种疫苗的孕妇中,82.91%会主动了解流感疫苗相关信息,87.18%了解流感传播途径。32.09%认为孕妇在孕期任何阶段都可接种流感疫苗。在不愿意和态度不确定的孕妇中,上述三个问题的比例分别为47.06%、83.95%和17.80%。在不愿意接种和态度不确定的孕妇中,疫苗犹豫的主要原因是担心孕期疫苗对孕妇和胎儿的安全性。多因素logistic回归分析显示,文化程度较高(=3.278,95%:1.678 - 6.406,=0.001)、孕中期(=1.542,95%:1.159 - 2.054,=0.003)、第三次怀孕(=2.318,95%:1.008 - 5.331,=0.048)以及既往接种过流感疫苗(=1.552,95%:1.119 - 2.152,=0.008)的孕妇孕期接种流感疫苗的意愿较高。上海市孕妇孕期接种流感疫苗的意愿相对较低,主要原因是担心疫苗安全性。