Yang Xianxian, Zheng Jiajing, Lv Xiaoyan, Wang Qing, Wang Dong, Xie Jiaxi, Ding Xianbin, Chen Ting
Chongqing Municipal Center for Disease Control and Prevention, Chongqing, China.
School of Public Health, Chongqing Medical University, Chongqing, China.
PLoS One. 2025 Jul 3;20(7):e0327012. doi: 10.1371/journal.pone.0327012. eCollection 2025.
Seasonal influenza is significantly associated with high morbidity and mortality. Vaccination of healthcare workers (HCWs), who represent a high-risk group, is a crucial preventive measure to reduce the spread of outbreaks and the severity of disease. Therefore, the aim of this study was to evaluate the levels of influenza vaccine acceptance and uptake, as well as the determinants influencing these factors among HCWs in Chongqing, China.
We conducted a cross-sectional survey among community HCWs aged ≥ 22 years from July 15, 2021 to September 30, 2021. An anonymous self-administered questionnaire was used to assess the knowledge and key factors of HCWs regarding vaccination acceptance and recommendation to patients. Parametric and nonparametric statistical analyses were performed with the use of the Statistical Program for the Social Sciences (SPSS) version 25.0.
The coverage rate for the seasonal influenza vaccination in Chongqing HCWs was 46.2% in the 2020-2021 seasons. HCWs who were females (OR: 2.10 95% CI: 1.54-2.85), had influenza experience (OR:1.98 95% 1.27-3.11), without influenza vaccination hesitancy (IVH) (OR:2.10 95% 1.58-2.79), and/or in a vaccination-promoted community (OR:6.50 95% 3.99-10.60) would be more likely to be vaccinated. HCWs who were vaccinated in 2020-2021 (OR: 8.48 95% 6.03-11.93), without IVH (OR: 4.15 95% 2.91-5.90), and/or in a vaccination-promoted community (OR: 2.08 95%1.37-3.16) would be more willing to be vaccinated. HCWs who were with knowledge scores ≥ 4 (OR: 2.58 95% 1.30-5.13), without IVH (OR: 2.33 95% 1.05-5.13), were in a vaccination-promoted community (OR: 2.65 95% 1.51-4.65), and/or with vaccination willingness (OR: 4.32 95% 2.16-8.64) would be more likely to recommend vaccination to patients.
The influenza vaccination rate among Chongqing HCWs increased in the 2020-2021 season but remained relatively low. It is critical to improve knowledge of influenza and its vaccine among HCWs, implement activities to moderate their IVH and expand the free vaccination policy, and interventional measures aiming to promote influenza vaccination.
季节性流感与高发病率和高死亡率显著相关。医护人员作为高危群体，接种疫苗是减少疫情传播和疾病严重程度的关键预防措施。因此，本研究旨在评估中国重庆医护人员的流感疫苗接受率和接种率，以及影响这些因素的决定因素。
2021年7月15日至2021年9月30日，我们对年龄≥22岁的社区医护人员进行了横断面调查。采用匿名自填问卷评估医护人员对疫苗接种接受情况及向患者推荐疫苗的知识和关键因素。使用社会科学统计程序（SPSS）25.0版进行参数和非参数统计分析。
2020 - 2021年季节，重庆医护人员的季节性流感疫苗接种率为46.2%。女性医护人员（比值比：2.10，95%置信区间：1.54 - 2.85）、有流感经历的医护人员（比值比：1.98，95%：1.27 - 3.11）、无流感疫苗接种犹豫（IVH）的医护人员（比值比：2.10，95%：1.58 - 2.79）和/或处于疫苗接种推广社区的医护人员（比值比：6.50，95%：3.99 - 10.60）更有可能接种疫苗。2020 - 2021年接种过疫苗的医护人员（比值比：8.48，95%：6.03 - 11.93）、无IVH的医护人员（比值比：4.15，95%：2.91 - 5.90）和/或处于疫苗接种推广社区的医护人员（比值比：2.08，95%：1.37 - 3.16）更愿意接种疫苗。知识得分≥4分的医护人员（比值比：2.58，95%：1.30 - 5.13）、无IVH的医护人员（比值比：2.33，95%：1.05 - 5.13）、处于疫苗接种推广社区的医护人员（比值比：2.65，95%：1.51 - 4.65）和/或有疫苗接种意愿的医护人员（比值比：4.32，95%：2.16 - 8.64）更有可能向患者推荐接种疫苗。
2020 - 2021年重庆医护人员的流感疫苗接种率有所上升，但仍相对较低。提高医护人员对流感及其疫苗的认识、开展活动减轻他们的IVH、扩大免费疫苗接种政策以及采取旨在促进流感疫苗接种的干预措施至关重要。
