在马拉维一家三级医院因重度急性营养不良入院的儿童中，广泛存在携带多种产超广谱头孢菌素耐药肠杆菌科细菌的情况。
Pervasive Intestinal Carriage with Multiple Species of Extended Spectrum Cephalosporin-Resistant Enterobacterales in Children Admitted for Severe Acute Malnutrition at a Tertiary Hospital in Malawi.
作者信息
Holowka Thomas, Ashford Arrington, Khuu Trieu-Vi, Bimagambetov Alisher, Dial Courtney N, Kondwani Alexander, Tepeka Amazing-Grace, Alby Kevin, Juliano Jonathan J, Garcia-Prats Anthony J, Mvalo Tisungane, Vonasek Bryan J, Ciccone Emily J, Bartelt Luther A
机构信息
Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
North Carolina Agricultural and Technical State University, Greensboro, NC, USA.
出版信息
medRxiv. 2025 May 31:2025.05.30.25328637. doi: 10.1101/2025.05.30.25328637.
Using culture-based screening of stool specimens, 80.3% of 188 children hospitalized for severe acute malnutrition in Malawi carried extended spectrum cephalosporin resistant Enterobacterales (ESCR-E) at admission. 38.3% of children were colonized with multiple ESCR-E species. Over half of the colonized children did not have recent antibiotic exposure or prior hospitalization.
通过对粪便标本进行基于培养的筛查，在马拉维因重度急性营养不良住院的188名儿童中，80.3%在入院时携带产超广谱头孢菌素耐药肠杆菌科细菌（ESCR-E）。38.3%的儿童被多种ESCR-E菌种定植。超过半数被定植的儿童近期未接触过抗生素，也未住院治疗过。
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