除草菌素A的杀支原体作用。
The mycoplasmacidal effect of herbicolin A.
作者信息
Birkelund S, Freundt E A
出版信息
J Antimicrob Chemother. 1985 Oct;16(4):449-55. doi: 10.1093/jac/16.4.449.
This study was to determine if the inhibitory effect of herbicolin A to sterol-requiring members of the class Mollicutes is due to a mycoplasmastatic or a mycoplasmacidal effect. Two strains were used as test organisms, Mycoplasma capricolum (California kid) and Ureaplasma urealyticum (T-960). Following exposure of the mycoplasmas to various inhibitory concentrations of herbicolin A for various periods of time, elimination of the antibiotic as a preliminary to demonstration of any surviving organisms was endeavoured by three different procedures: (a) serial dilution, (b) filtration through a membrane filter, and (c) separation of the organisms by centrifugation. The results of these experiments showed a mycoplasmacidal effect of herbicolin A.
本研究旨在确定除草菌素A对支原体纲中需要固醇的成员的抑制作用是由于支原体生长抑制还是杀支原体作用。使用了两种菌株作为测试生物，即山羊支原体（加利福尼亚株）和解脲脲原体（T-960）。在将支原体暴露于不同抑制浓度的除草菌素A不同时间后，通过三种不同程序努力去除抗生素，作为证明任何存活生物的初步步骤：（a）连续稀释，（b）通过膜过滤器过滤，以及（c）通过离心分离生物。这些实验结果显示了除草菌素A的杀支原体作用。
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