切除的和原位犬肺叶中的肺泡外血管液体滤过系数

Extra-alveolar vessel fluid filtration coefficients in excised and in situ canine lobes.

作者信息

Albert R K, Kirk W, Pitts C, Butler J

出版信息

J Appl Physiol (1985). 1985 Nov;59(5):1555-9. doi: 10.1152/jappl.1985.59.5.1555.

DOI:10.1152/jappl.1985.59.5.1555

Abstract

We continuously weighed fully distended excised or in situ canine lobes to estimate the fluid filtration coefficient (Kf) of the arterial and venous extra-alveolar vessels compared with that of the entire pulmonary circulation. Alveolar pressure was held constant at 25 cmH2O after full inflation. In the in situ lobes, the bronchial circulation was interrupted by embolization. Kf was estimated by two methods (Drake and Goldberg). Extra-alveolar vessels were isolated from alveolar vessels by embolizing enough 37- to 74-micron polystyrene beads into the lobar artery or vein to completely stop flow. In excised lobes, Kf's of the entire pulmonary circulation by the Drake and Goldberg methods were 0.122 +/- 0.041 (mean +/- SD) and 0.210 +/- 0.080 ml X min-1 X mmHg-1 X 100 g lung-1, respectively. Embolization was not found to increase the Kf's. The mean Kf's of the arterial extra-alveolar vessels were 0.068 +/- 0.014 (Drake) and 0.069 +/- 0.014 (Goldberg) (24 and 33% of the Kf's for the total pulmonary circulation). The mean Kf's of the venous extra-alveolar vessels were similar [0.046 +/- 0.020 (Drake) and 0.065 +/- 0.036 (Goldberg) or 33 and 35% of the Kf's for the total circulation]. No significant difference was found between the extra-alveolar vessel Kf's of in situ vs. excised lobes. These results suggest that when alveolar pressure, lung volume, and pulmonary vascular pressures are high, approximately one-third of the total fluid filtration comes from each of the three compartments.

摘要

我们持续称量完全膨胀的离体或原位犬肺叶重量，以估算动脉和静脉肺泡外血管的液体滤过系数（Kf），并与整个肺循环的Kf进行比较。充分充气后，肺泡压力维持在25 cmH₂O不变。对于原位肺叶，通过栓塞阻断支气管循环。采用两种方法（德雷克法和戈德堡法）估算Kf。通过向叶动脉或叶静脉内注入足够数量的37至74微米的聚苯乙烯珠，使血流完全停止，从而将肺泡外血管与肺泡血管分离。在离体肺叶中，采用德雷克法和戈德堡法测得的整个肺循环的Kf分别为0.122±0.041（均值±标准差）和0.210±0.080 ml·min⁻¹·mmHg⁻¹·100 g肺组织⁻¹。未发现栓塞会增加Kf。动脉肺泡外血管的平均Kf分别为0.068±0.014（德雷克法）和0.069±0.014（戈德堡法）（分别为整个肺循环Kf的24%和33%）。静脉肺泡外血管的平均Kf相似[0.046±0.020（德雷克法）和0.065±0.036（戈德堡法），分别为整个肺循环Kf的33%和35%]。原位肺叶和离体肺叶的肺泡外血管Kf之间未发现显著差异。这些结果表明，当肺泡压力、肺容积和肺血管压力较高时，总液体滤过的约三分之一分别来自三个部分中的每一个。