Makrantonaki Evgenia, Kostaras Spyridon, Zouboulis Christos C
Abteilungen für Dermatologie, Venerologie, Allergologie und Immunologie, Dessau Medical Center, Brandenburg Medizinische Hochschule Theodor Fontane, Auenweg 38, 06847, Dessau, Deutschland.
Derma Zentrum Wildeshausen, Westerstr. 46-48, 27793, Wildeshausen, Deutschland.
Dermatologie (Heidelb). 2025 Jan;76(1):9-14. doi: 10.1007/s00105-024-05441-5. Epub 2024 Dec 6.
Diabetes mellitus (DM) is a debilitating, life-limiting disease. According to recent estimates, 415 million adults currently suffer from the disease. This number is expected to rise to 642 million by 2040. Skin disorders can often predict the onset of this metabolic disorder. Uncontrolled hyperglycemia impairs the overall immunity of patients with DM, involving various mechanistic pathways, resulting in the diabetic skin being immunocompromised and prone to bacterial infections. Among others, diabetic foot infections are very common. In this article, we have focused on the association of DM with different types of bacterial skin infections and resistance patterns to antimicrobial agents commonly used in the treatment of diabetes-associated infections.
糖尿病（DM）是一种使人衰弱、危及生命的疾病。根据最近的估计，目前有4.15亿成年人患有这种疾病。预计到2040年，这一数字将增至6.42亿。皮肤疾病常常可以预测这种代谢紊乱疾病的发作。血糖控制不佳会损害糖尿病患者的整体免疫力，涉及多种机制途径，导致糖尿病皮肤免疫功能受损，容易发生细菌感染。其中，糖尿病足感染非常常见。在本文中，我们重点关注了糖尿病与不同类型细菌性皮肤感染的关联以及对糖尿病相关感染常用抗菌药物的耐药模式。
