Wang Yujing, Xue Yu, Xu Huan, Zhu Qian, Qin Kaili, He Zhonglei, Huang Aixiang, Mu Min, Tao Xinrong
Joint Research Center for Occupational Medicine and Health of IHM, Anhui University of Science and, Technology, Huainan 232000, China.
School of Public Health, Anhui University of Science and Technology, Hefei 231131, China.
Food Funct. 2025 Jan 20;16(2):554-569. doi: 10.1039/d4fo04301d.
Obesity-related metabolic syndrome is intimately associated with infiltrated adipose tissue macrophages (ATMs), gut microbiota, and metabolic disorders. holds the potential to mitigate obesity; however, there exist strain-specific functionalities and diverse mechanisms, which deserve extensive exploration. This study aims to explore the potential of Y01, isolated from traditional sour whey, in alleviating HFD-induced metabolic syndrome in mice and elucidating its underlying mechanism. The results showed that Y01 could inhibit the increase of body weight gain, the deposition of fat, lipid disorders and chronic low-grade inflammation, improve glucose tolerance and insulin resistance, and could reduce adipose tissue inflammation by decreasing M1-type ATMs and increasing M2-type ATMs. Meanwhile, Y01 significantly increased the abundance of potentially beneficial intestinal bacteria, such as , , , , , , and , and partially restored the levels of metabolites, such as phosphatidylcholines, glycerophosphocholines, sphingolipids and unsaturated fatty acids. The fecal microbiota transplantation experiment demonstrated that Y01 ameliorated obesity-related metabolic syndrome by modulating the polarization of M1/M2 ATMs mediated by gut microbiota. Overall, as a dietary supplement, Y01 has good potential in the prevention and treatment of obesity.
肥胖相关的代谢综合征与浸润性脂肪组织巨噬细胞（ATMs）、肠道微生物群和代谢紊乱密切相关。[前文未提及的某物质]有减轻肥胖的潜力；然而，存在菌株特异性功能和多种机制，值得深入探索。本研究旨在探讨从传统酸乳清中分离出的Y01在减轻高脂饮食诱导的小鼠代谢综合征及其潜在机制方面的潜力。结果表明，Y01可以抑制体重增加、脂肪沉积、脂质紊乱和慢性低度炎症，改善葡萄糖耐量和胰岛素抵抗，并通过减少M1型ATMs和增加M2型ATMs来减轻脂肪组织炎症。同时，Y01显著增加了潜在有益肠道细菌的丰度，如[列举的多种细菌名称]，并部分恢复了代谢物的水平，如磷脂酰胆碱、甘油磷酸胆碱、鞘脂和不饱和脂肪酸。粪便微生物群移植实验表明，Y01通过调节肠道微生物群介导的M1/M2 ATMs极化来改善肥胖相关的代谢综合征。总体而言，作为一种膳食补充剂，Y01在肥胖的预防和治疗方面具有良好的潜力。
