Niemi L, Syrjänen S, Hensten-Pettersen A
J Biomed Mater Res. 1985 May-Jun;19(5):535-48. doi: 10.1002/jbm.820190506.
The biocompatibility of type III casting gold alloy, an Ag-Pd-Cu-Au-based dental casting alloy and its two main structural components, a CuPd-rich and an Ag-rich phase, was studied after subcutaneous implantation for 7 weeks in 20 guinea pigs. The Ag-Pd-Cu-Au alloy was surrounded by a capsule of immature collagen with fibroblasts and an increased vascular supply. The CuPd-rich component induced and maintained an acute inflammation with highly vascularized granulation tissue. The tissue reaction to the Ag-rich component and the Au-based alloy was slight. Ten of the guinea pigs were sensitized to PdCl2 prior to the implantation period, but this caused no enhanced tissue reaction, except for an increase in the number of mast cells around three of the alloys.
研究了一种基于银 - 钯 - 铜 - 金的牙科铸造合金Ⅲ型铸造金合金及其两个主要结构成分（富铜钯相和富银相）在20只豚鼠皮下植入7周后的生物相容性。银 - 钯 - 铜 - 金合金被含有成纤维细胞的未成熟胶原胶囊包围，血管供应增加。富铜钯成分诱导并维持了伴有高度血管化肉芽组织的急性炎症。对富银成分和金基合金的组织反应轻微。十只豚鼠在植入期前对氯化钯致敏，但这并未导致组织反应增强，只是三种合金周围的肥大细胞数量有所增加。
