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复发性棕色瘤作为原发性甲状旁腺功能亢进的首发症状：一例报告

Recurrent Brown Tumors as a Presenting Complaint of Primary Hyperparathyroidism: A Case Report.

作者信息

Saad Muhammad, Syed Muhammad Rayan, Hamza Ifrah, Dureshum F N U, Anns Khizer Masroor, Aslam Hamza, Syed Aleeza, Khan Faheemullah, Faraz Ijaz

机构信息

Liaquat University of Medical and Health Sciences Jamshoro Pakistan.

People's University of Medical and Health Sciences Shaheed Benazirabad Pakistan.

出版信息

Clin Case Rep. 2025 Jul 14;13(7):e70624. doi: 10.1002/ccr3.70624. eCollection 2025 Jul.

DOI:10.1002/ccr3.70624
PMID:40667494
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12259391/
Abstract

Brown tumor is a rare complication of hyperparathyroidism caused by bony remodeling. These tumors usually affect long bones, pelvis, and ribs, although every bone of the body can be involved. We report a case of a 36-year-old female who presented with complaints of swellings on the right mandible and left maxillary region. She had a history of a similar swelling on the right side of the maxilla that was excised surgically. This time, her incisional biopsy and lab work confirmed the diagnosis of brown tumors secondary to hyperparathyroidism. Parathyroidectomy was done for parathyroid adenoma, and the postoperative period was uneventful. Although brown tumor is rarely seen in clinical practice nowadays due to early detection of hyperparathyroidism, it is still an important differential diagnosis of bony tumors and oral masses.

摘要

棕色瘤是一种由骨重塑引起的甲状旁腺功能亢进的罕见并发症。这些肿瘤通常累及长骨、骨盆和肋骨，不过身体的每块骨头都可能受累。我们报告一例36岁女性病例，她因右侧下颌骨和左侧上颌区域肿胀前来就诊。她有上颌右侧类似肿胀的手术切除病史。此次，她的切口活检及实验室检查确诊为继发于甲状旁腺功能亢进的棕色瘤。因甲状旁腺腺瘤行甲状旁腺切除术，术后恢复顺利。尽管由于甲状旁腺功能亢进的早期发现，如今棕色瘤在临床实践中很少见，但它仍是骨肿瘤和口腔肿物的重要鉴别诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34b1/12259391/0653a1299cce/CCR3-13-e70624-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34b1/12259391/d9484128611b/CCR3-13-e70624-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34b1/12259391/2390c049f927/CCR3-13-e70624-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34b1/12259391/acd528ea5a6f/CCR3-13-e70624-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34b1/12259391/bf5869b0e93f/CCR3-13-e70624-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34b1/12259391/64a12bac2fba/CCR3-13-e70624-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34b1/12259391/0653a1299cce/CCR3-13-e70624-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34b1/12259391/d9484128611b/CCR3-13-e70624-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34b1/12259391/2390c049f927/CCR3-13-e70624-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34b1/12259391/acd528ea5a6f/CCR3-13-e70624-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34b1/12259391/bf5869b0e93f/CCR3-13-e70624-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34b1/12259391/64a12bac2fba/CCR3-13-e70624-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34b1/12259391/0653a1299cce/CCR3-13-e70624-g001.jpg

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本文引用的文献

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Brown tumor due to primary hyperparathyroidism in a familial case: a case report.家族性原发性甲状旁腺功能亢进致棕色瘤 1 例报告。
BMC Endocr Disord. 2023 Oct 8;23(1):214. doi: 10.1186/s12902-023-01475-3.
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Brown tumor of the cervical spine with primary hyperparathyroidism: A case report and literature review.原发性甲状旁腺功能亢进致颈椎棕色瘤 1 例报告并文献复习
Medicine (Baltimore). 2023 Feb 10;102(6):e32768. doi: 10.1097/MD.0000000000032768.
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Epidemiology, Pathophysiology, and Genetics of Primary Hyperparathyroidism.原发性甲状旁腺功能亢进的流行病学、病理生理学和遗传学。
J Bone Miner Res. 2022 Nov;37(11):2315-2329. doi: 10.1002/jbmr.4665. Epub 2022 Oct 17.
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Haematological manifestations in primary hyperparathyroidism.原发性甲状旁腺功能亢进的血液学表现。
Indian J Med Res. 2022 Jan;155(1):43-48. doi: 10.4103/ijmr.IJMR_1200_19.
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Parathyroid Imaging: Past, Present, and Future.甲状旁腺成像：过去、现在和未来。
Front Endocrinol (Lausanne). 2022 Feb 25;12:760419. doi: 10.3389/fendo.2021.760419. eCollection 2021.
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A patient with multiple brown tumors due to secondary hyperparathyroidism: A case report.一例因继发性甲状旁腺功能亢进导致多发棕色瘤的患者：病例报告
Radiol Case Rep. 2021 Jul 2;16(9):2482-2486. doi: 10.1016/j.radcr.2021.06.015. eCollection 2021 Sep.
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Gnathic Bones and Hyperparathyroidism: A Review on the Metabolic Bony Changes Affecting the Mandible and Maxilla in case of Hyperparathyroidism.颌骨与甲状旁腺功能亢进症：甲状旁腺功能亢进时影响下颌骨和上颌骨的代谢性骨变化综述
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Brown tumor of the jaws as a manifestation of tertiary hyperparathyroidism: A literature review and case report.颌骨棕色瘤作为三发性甲状旁腺功能亢进的一种表现：文献综述与病例报告
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Thorac Cancer. 2013 Nov;4(4):474-478. doi: 10.1111/1759-7714.12045.