Putri Almahitta Cintami, Soedjana Hardisiswo, Hasibuan Lisa, Sundoro Ali, Septrina Rani, Sisca Fransisca
Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine, Universitas Padjajaran (FK UNPAD) - Dr. Hasan Sadikin Hospital, Bandung, Indonesia.
Int Wound J. 2025 Jul;22(7):e70458. doi: 10.1111/iwj.70458.
Pressure injury is soft tissue damage caused by persistent mechanical pressure on bony prominences, with incidence rates continuing to rise. To address this issue, platelet-rich plasma (PRP) is being researched and developed. This study aims to compare the effects of injectable and topical PRP administration on pressure injury healing, using the Pressure Ulcer Scale for Healing (PUSH) score and collagen density as measures. This experimental study was conducted with grade III and IV pressure injury patients treated at a tertiary referral hospital in Bandung. The subjects were divided into three groups: control, PRP injection and topical PRP. Wound treatment and observation were conducted over 21 days, with evaluations based on the PUSH score (wound area, exudate amount and tissue type) and collagen density. This study involved 22 patients with 30 pressure ulcers. Significant differences were observed in the mean Δ PUSH score (p = 0.047) and mean Δ collagen density (p = 0.011) in the PRP injection group compared to the control group. No significant differences were found between the PRP injection and topical PRP groups regarding PUSH score (p = 0.162) and collagen density (p = 0.862). In the PRP injection group, a significant decrease in the PUSH score was observed on day 12 (p = 0.045), whilst in the topical PRP group, a significant decrease occurred on day 21 (p = 0.034). PRP injection significantly reduces PUSH scores and increases collagen density compared to the control group. By day 21, no significant differences were observed between PRP injection and topical PRP. However, PRP injection demonstrated faster clinical improvement, with significant changes in PUSH score evident by day 12, compared to day 21 for topical PRP.
压力性损伤是由骨隆突处持续的机械压力导致的软组织损伤，其发病率持续上升。为解决这一问题，富含血小板血浆（PRP）正在被研究和开发。本研究旨在以愈合压力性溃疡量表（PUSH）评分和胶原蛋白密度作为衡量指标，比较注射用和外用PRP给药对压力性损伤愈合的影响。本实验研究在万隆一家三级转诊医院对III级和IV级压力性损伤患者进行。受试者分为三组：对照组、PRP注射组和外用PRP组。伤口治疗和观察持续21天，根据PUSH评分（伤口面积、渗出物量和组织类型）和胶原蛋白密度进行评估。本研究纳入了22例患者的30处压力性溃疡。与对照组相比，PRP注射组的平均ΔPUSH评分（p = 0.047）和平均Δ胶原蛋白密度（p = 0.011）存在显著差异。PRP注射组和外用PRP组在PUSH评分（p = 0.162）和胶原蛋白密度（p = 0.862）方面未发现显著差异。在PRP注射组，第12天观察到PUSH评分显著降低（p = 0.045），而在外用PRP组，第21天出现显著降低（p = 0.034）。与对照组相比，PRP注射显著降低PUSH评分并增加胶原蛋白密度。到第21天，PRP注射组和外用PRP组之间未观察到显著差异。然而，PRP注射显示出更快的临床改善，与外用PRP在第21天相比，第12天PUSH评分就有明显的显著变化。
