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骨质疏松性椎体骨折:最新进展

Osteoporotic vertebral fractures: an update.

作者信息

Daskalakis Ioannis I, Bastian Johannes D, Mavrogenis Andreas F, Tosounidis Theodoros H

机构信息

Department of Orthopaedic Surgery, Medical School, University of Crete, 71110 Heraklion, Greece.

Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.

出版信息

SICOT J. 2025;11:40. doi: 10.1051/sicotj/2025035. Epub 2025 Jul 16.

DOI:10.1051/sicotj/2025035
PMID:40668980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12266666/
Abstract

INTRODUCTION

Osteoporotic vertebral fractures (OVFs) are the most common type of fragility fractures. They have a significant and usually detrimental impact on the patient's functional status and mortality rate, constituting a substantial burden for the patients, their families, and the healthcare system. This narrative review aims to summarize the current knowledge of osteoporotic vertebral fractures and secondary fracture prevention.

METHODS

A comprehensive literature search was conducted across major medical databases, including PubMed, Scopus, and Web of Science. Relevant studies, guidelines, and reviews published were analyzed to provide a broad perspective on the topic.

RESULTS

Diagnosis of OVFs is based on history, clinical examination, and plain lateral radiographs of the spine. Their management is mainly non-operative, with surgery being reserved for specific indications. Successful management of osteoporotic vertebral fractures entails alleviating pain, early restoration of mobility, and secondary fracture prevention. Prevention of the next osteoporotic fracture is paramount and should be an integral element of their management. The Fracture Liaison Service (FLS) is the main contemporary service that serves this purpose.

DISCUSSION

Diagnosis of OVFs is simple but requires vigilance from the clinicians. Early, accurate diagnosis is essential to initiate appropriate treatment and provide the opportunity for secondary fracture prevention.

摘要

引言

骨质疏松性椎体骨折(OVF)是最常见的脆性骨折类型。它们对患者的功能状态和死亡率有重大且通常是有害的影响,给患者及其家庭以及医疗保健系统带来沉重负担。本叙述性综述旨在总结骨质疏松性椎体骨折及继发性骨折预防的当前知识。

方法

在包括PubMed、Scopus和Web of Science在内的主要医学数据库中进行了全面的文献检索。对已发表的相关研究、指南和综述进行分析,以提供关于该主题的广泛视角。

结果

OVF的诊断基于病史、临床检查和脊柱的普通侧位X线片。其治疗主要是非手术治疗,手术仅适用于特定指征。骨质疏松性椎体骨折的成功治疗需要缓解疼痛、早期恢复活动能力以及预防继发性骨折。预防下一次骨质疏松性骨折至关重要,应是其治疗的一个组成部分。骨折联络服务(FLS)是目前为此目的服务的主要服务项目。

讨论

OVF的诊断简单,但需要临床医生保持警惕。早期、准确的诊断对于启动适当治疗和提供继发性骨折预防机会至关重要。

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本文引用的文献

1
Radiological Diagnosis and Advances in Imaging of Vertebral Compression Fractures.椎体压缩骨折的放射学诊断与影像学进展
J Imaging. 2024 Sep 28;10(10):244. doi: 10.3390/jimaging10100244.
2
Fractures of the proximal femur and hip osteoarthrosis - coincidence or coherence?股骨近端骨折与髋骨关节炎——是巧合还是存在关联?
SICOT J. 2024;10:29. doi: 10.1051/sicotj/2024027. Epub 2024 Aug 19.
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Isolated posterior stabilization in type B and C thoracolumbar fractures associated with ankylosing spine disorders: A single center experience with clinical and radiological outcomes.B型和C型胸腰椎骨折合并强直性脊柱炎疾病的单纯后路稳定术:单中心临床及影像学结果经验
SICOT J. 2024;10:26. doi: 10.1051/sicotj/2024022. Epub 2024 Aug 9.
4
Effectiveness of fracture liaison service in reducing the risk of secondary fragility fractures in adults aged 50 and older: a systematic review and meta-analysis.骨折联络服务降低 50 岁及以上成年人继发性脆性骨折风险的有效性:系统评价和荟萃分析。
Osteoporos Int. 2024 Jul;35(7):1133-1151. doi: 10.1007/s00198-024-07052-1. Epub 2024 Mar 27.
5
Application of an in-hospital, surgeon-led anti-osteoporotic medication algorithm in patients with hip fractures improves persistence to medication and can prevent the second fragility fracture.院内外科医生主导的抗骨质疏松药物治疗方案可提高髋部骨折患者的药物依从性,并预防再次脆性骨折。
Arch Orthop Trauma Surg. 2024 Feb;144(2):683-692. doi: 10.1007/s00402-023-05132-1. Epub 2023 Dec 3.
6
Can nutritional and inflammatory indices predict 90-day mortality in fragility hip fracture patients?营养和炎症指标能否预测脆性髋部骨折患者90天死亡率?
SICOT J. 2023;9:30. doi: 10.1051/sicotj/2023029. Epub 2023 Oct 30.
7
Secondary Fracture Rate After Vertebral Osteoporotic Compression Fracture Is Decreased by Anti-Osteoporotic Medication but Not Increased by Cement Augmentation.抗骨质疏松药物可降低椎体骨质疏松性压缩骨折后的二次骨折发生率,但骨水泥强化不会增加该发生率。
J Bone Joint Surg Am. 2022 Dec 21;104(24):2178-2185. doi: 10.2106/JBJS.22.00469. Epub 2022 Oct 12.
8
Cost-effectiveness studies of vertebral augmentation for osteoporotic vertebral fractures: a systematic review.骨质疏松性椎体骨折椎体增强治疗的成本效益研究:系统评价。
Spine J. 2022 Aug;22(8):1356-1371. doi: 10.1016/j.spinee.2022.02.013. Epub 2022 Mar 5.
9
Systematic Review and Meta-Analysis of 3 Treatment Arms for Vertebral Compression Fractures: A Comparison of Improvement in Pain, Adjacent-Level Fractures, and Quality of Life Between Vertebroplasty, Kyphoplasty, and Nonoperative Management.椎体压缩骨折三种治疗方法的系统评价与荟萃分析:椎体成形术、后凸成形术与非手术治疗在疼痛改善、相邻节段骨折及生活质量方面的比较
JBJS Rev. 2021 Oct 25;9(10):01874474-202110000-00006. doi: e21.00045.
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A Pilot Study of Radiculopathy Following Osteoporotic Vertebral Fracture in Elderly Patients: An Algorithmic Approach to Surgical Management.老年患者骨质疏松性椎体骨折后神经根病的初步研究:手术治疗的算法方法
Geriatr Orthop Surg Rehabil. 2021 Sep 26;12:21514593211044912. doi: 10.1177/21514593211044912. eCollection 2021.