Nutzinger D O, Cayiroglu S, Sachs G, Zapotoczky H G
J Behav Ther Exp Psychiatry. 1985 Sep;16(3):217-21. doi: 10.1016/0005-7916(85)90066-7.
Depressive symptoms may increase in a subgroup of obese individuals shortly after beginning a weight-reducing diet. Therefore an additional antidepressive medication should have a positive effect on the course and results of therapy. This hypothesis was tested in three different institutional settings, with identical therapeutic programs. In this study there were 23 obese women. Therapeutic strategies were concerned with an increase of self-control over eating behavior, the improvement of social skills, and the establishment of new problem-solving abilities. Doxepin was used as the anti-depressant in a double blind procedure. Our results seem to support the hypothesis of this study: depressive symptoms markedly increased soon after the beginning of weight-reduction; additional antidepressive medication helped to improve the symptoms and in the long term had a positive effect on the rate of weight loss.
在开始减肥饮食后不久，肥胖个体的一个亚组中抑郁症状可能会增加。因此，额外的抗抑郁药物应对治疗过程和结果产生积极影响。该假设在三种不同的机构环境中，采用相同的治疗方案进行了测试。本研究中有23名肥胖女性。治疗策略涉及增强对饮食行为的自我控制、提高社交技能以及培养新的解决问题的能力。多塞平在双盲程序中用作抗抑郁药。我们的结果似乎支持了本研究的假设：减肥开始后不久，抑郁症状明显增加；额外的抗抑郁药物有助于改善症状，从长期来看对减肥率有积极影响。
