Subasi Bilge Su, Hayri-Senel Tugba, Kahraman Ebru, Sezer Serhat, Nasun-Saygili Gulhayat, Erdol-Aydin Nalan
Faculty of Chemical and Metallurgical Engineering, Department of Chemical Engineering, Istanbul Technical University, Istanbul, Turkey.
Sci Rep. 2025 Jul 17;15(1):25894. doi: 10.1038/s41598-025-11502-z.
The increasing presence of antibiotics such as tetracycline (TC) in aquatic environments has become a critical issue due to their persistence and contribution to antibiotic resistance. In this study, a graphene oxide and hydroxyapatite (GO-HAp) composite was synthesized as photocatalyst, and its performance for visible-light-induced degradation of TC from aqueous solution was evaluated. The incorporation of GO reduced the band gap of HAp from 3.5 eV to 2.8 eV, thereby enhancing the photocatalytic efficiency. The evaluation and optimization of the process parameters including pH, initial TC concentration, and catalyst dosage were carried out using Box-Behnken Design (BBD). Under the optimum conditions (pH 11, 50 mg L TC, 15 mg catalyst), a degradation efficiency of 86.65% was obtained after 120 min of irradiation. Kinetic analysis showed that the degradation followed a pseudo-first-order model with an R value of 0.95. Additionally, the photocatalyst synthesized in the study exhibited good reusability and showed an efficiency of 83% after three cycles. These results indicate that the GO-HAp composite is a promising and reusable material for the efficient photodegradation of tetracycline under visible light.
由于四环素（TC）等抗生素在水生环境中的持续存在及其对抗生素耐药性的影响，其在水环境中日益增加的存在已成为一个关键问题。在本研究中，合成了氧化石墨烯和羟基磷灰石（GO-HAp）复合材料作为光催化剂，并评估了其在可见光诱导下从水溶液中降解TC的性能。GO的掺入将HAp的带隙从3.5 eV降低到2.8 eV，从而提高了光催化效率。使用Box-Behnken设计（BBD）对包括pH值、初始TC浓度和催化剂用量在内的工艺参数进行了评估和优化。在最佳条件下（pH 11、50 mg/L TC、15 mg催化剂），照射120分钟后降解效率达到86.65%。动力学分析表明，降解遵循伪一级模型，R值为0.95。此外，本研究中合成的光催化剂表现出良好的可重复使用性，经过三个循环后效率仍为83%。这些结果表明，GO-HAp复合材料是一种有前途的可重复使用材料，可在可见光下高效光降解四环素。
