Santis Emiliano De, André Tomas, Alleva Stefania, Bean Richard, Ferrario Massimo, Marcelli Augusto, Minicozzi Velia, Principi Emiliano, Tîmneanu Nicuşor, Caleman Carl, Stellato Francesco
Department of Physics, University of Rome Tor Vergata and INFN, Via della Ricerca Scientifica 1, 00133, Rome, Italy.
Department of Physics and Astronomy, Uppsala University, Box 516, 75120, Uppsala, Sweden.
Eur Biophys J. 2025 Jul 16. doi: 10.1007/s00249-025-01778-4.
The EuPRAXIA project is a European initiative aimed at developing groundbreaking, ultra-compact accelerator research infrastructures based on novel plasma acceleration concepts. The EuPRAXIA@SPARC_LAB facility, located in the Italian National Institute for Nuclear Physics-Frascati National Laboratory, will be the first operating Free Electron Laser facility of EuPRAXIA, based on an accelerator module driven by an electron bunch driver. The Free Electron Laser will produce ultra-short photon pulses in the soft X-ray region. The photons will be delivered to an endstation, called AQUA, to perform a wide range of experiments in atomic and molecular physics, chemistry, and life sciences for both academic and industrial users. Thanks to its wavelength, which falls within the so-called 'water window', AQUA will be particularly well-suited for coherent imaging and ion spectroscopy measurements on biological samples at room temperature in a fully hydrated environment. This unique capability opens up innovative experimental schemes for studying biological systems in states that closely resemble their physiological conditions. This paper presents numerical simulations of coherent diffraction imaging and Coulomb explosion imaging experiments, anticipating future studies at AQUA on biological samples.
EuPRAXIA项目是一项欧洲倡议，旨在基于新型等离子体加速概念开发具有开创性的超紧凑型加速器研究基础设施。位于意大利国家核物理研究所-弗拉斯卡蒂国家实验室的EuPRAXIA@SPARC_LAB设施将成为EuPRAXIA的首个运行中的自由电子激光设施，它基于由电子束驱动器驱动的加速器模块。该自由电子激光将在软X射线区域产生超短光子脉冲。这些光子将被输送到一个名为AQUA的终端站，供学术和工业用户进行原子与分子物理、化学及生命科学等领域的广泛实验。由于其波长处于所谓的“水窗”范围内，AQUA将特别适合在完全水合环境下对室温下的生物样品进行相干成像和离子光谱测量。这种独特能力为研究与生理条件极为相似状态下的生物系统开辟了创新的实验方案。本文介绍了相干衍射成像和库仑爆炸成像实验的数值模拟，预期未来将在AQUA上对生物样品展开研究。
