间歇性伊斯兰禁食对代谢综合征管理的影响：一项随机对照试验。
Effect of intermittent Islamic fasting in management of metabolic syndrome: a randomized control trial.
作者信息
Nofal Hanaa A, Elmor Abdellatif Abd-El Rahman, AbdAllah Amany M, Zaitoun Nermeen A, Andargeery Shaherah Yousef, Sharafeddin Mahmoud A, Hassan Radwa Ibrahim Ali, Elhawy Lamiaa Lotfy
机构信息
Public health and community medicine department, Faculty of Medicine, Zagazig University, Zagazig, Sharkia, Egypt.
Family Medicine department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
出版信息
BMC Public Health. 2025 Jul 16;25(1):2476. doi: 10.1186/s12889-025-23493-7.
BACKGROUND
Metabolic syndrome doubles the risk of developing cardiovascular diseases and type II diabetes mellitus. Intermittent Islamic fasting is an effective health strategy associated with various benefits.
OBJECTIVES
to compare effect of intermittent Islamic fasting with lifestyle modification versus lifestyle modification only on weight management, blood pressure, blood glucose and lipid profile among a group of metabolic syndrome patients.
METHODS
A Randomized control trial was conducted on (54 patients) with metabolic syndrome, their ages range from (30-45 years) attending the clinical nutrition outpatient clinic in the Zagazig University hospital from 1st of August (2023) to the end of February (2024). Intervention group (27 patients) followed Islamic fasting with lifestyle modification (Islamic fasting means: fasting two days per week (Monday and Thursday) with fasting (13, 14, 15) middle of lunar months) and control group (27 patients) followed lifestyle modification only.
RESULTS
There is statistically non-significant difference between groups regarding healthy lifestyle score, clinical or laboratory parameters. There is statistically significant difference between the studied groups regarding percent of change in weight (p-value < 0.001), waist circumference (P-value < 0.001), systolic ( p-value = 0.042), diastolic blood pressure (P < 0.001), Fasting blood glucose (p-vale < 0.001), triglycerides (p-value < 0.001), HDL(p-value < 0.001) and total cholesterol (p-value = 0.023) with better improvement in intervention group, although no significant difference between them regrading lifestyle before or after intervention but both groups showed significant improvement after intervention.
CONCLUSION
Intermittent Islamic fasting (ISF) demonstrated a statistically significant enhancement in weight regulation, systolic blood pressure, triglyceride levels, total cholesterol, and HDL concentrations when compared to lifestyle modification alone.
TRIAL REGISTRATION
Retrospectively registered on ClinicalTrials.gov, registered at 22/1/ 2025, Identifier NCT06805526.
背景
代谢综合征使患心血管疾病和2型糖尿病的风险加倍。间歇性伊斯兰禁食是一种与多种益处相关的有效健康策略。
目的
比较间歇性伊斯兰禁食联合生活方式改变与单纯生活方式改变对一组代谢综合征患者体重管理、血压、血糖和血脂谱的影响。
方法
对54例年龄在30至45岁之间的代谢综合征患者进行了一项随机对照试验，这些患者于2023年8月1日至2024年2月底在扎加齐格大学医院临床营养门诊就诊。干预组（27例患者）采用伊斯兰禁食联合生活方式改变（伊斯兰禁食意味着：每周禁食两天（周一和周四），在农历月中旬禁食13、14、15天），对照组（27例患者）仅采用生活方式改变。
结果
在健康生活方式评分、临床或实验室参数方面，两组之间无统计学显著差异。在体重变化百分比（p值<0.001）、腰围（P值<0.001）、收缩压（p值=0.042）、舒张压（P<0.001）、空腹血糖（p值<0.001）、甘油三酯（p值<0.001）、高密度脂蛋白（p值<0.001）和总胆固醇（p值=0.023）方面，研究组之间存在统计学显著差异，干预组改善更好，尽管两组在干预前后的生活方式方面无显著差异，但两组在干预后均显示出显著改善。
结论
与单纯生活方式改变相比，间歇性伊斯兰禁食在体重调节、收缩压、甘油三酯水平、总胆固醇和高密度脂蛋白浓度方面显示出统计学显著改善。
试验注册
在ClinicalTrials.gov上进行回顾性注册，于2025年1月22日注册，标识符为NCT06805526。
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