斋月日间间歇性禁食和同时训练对肥胖管理的有效性：这种结合是否值得？

Effectiveness of Ramadan diurnal intermittent fasting and concurrent training in the management of obesity: is the combination worth the weight?

机构信息

High Institute of Sport and Physical Education of Sfax, University of Sfax, Tunisia; Research Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine, University of Sfax, Tunisia.

High Institute of Sport and Physical Education of Sfax, University of Sfax, Tunisia; Research Laboratory of Evaluation and Management of Musculoskeletal System Pathologies, LR20ES09, University of Sfax, Tunisia.

出版信息

Nutr Metab Cardiovasc Dis. 2023 Mar;33(3):659-666. doi: 10.1016/j.numecd.2022.12.004. Epub 2022 Dec 20.

DOI:10.1016/j.numecd.2022.12.004

PMID:36710112

Abstract

BACKGROUND AND AIMS

We investigated, in men with obesity, the efficacy of the combination of two strategies (Ramadan diurnal intermittent fasting 'RDIF' strategy vs RDIF plus concurrent training program 'RDIF-CT' strategy) known for their positive impact on body composition and then we explored the possible impact on metabolic and inflammatory biomarkers.

METHODS AND RESULTS

Twenty obese men, age: 31.8 ± 7.05 years, BMI: 33.1 ± 4.2 kg m, performing regularly RDIF, were randomized into two groups: RDIF-CT (n = 10) and RDIF without training (RDIF-NCT) (n = 10). The RDIF-CT group participated in High intensity interval training (HIIT) program combined with resistance exercises for 4 weeks. Body composition, blood glucose, lipid profile, liver biomarkers and inflammation were assessed before and after 4-week RDIF. Both groups showed a significant decrease in weight, fat mass (FM), fat percentage (Fat%) and waist circumference (WC) and an improvement in blood glucose, lipid profile and inflammation. Fat free mass decreased significantly in RDIF-NCT (p < 0.05) while remaining unchanged in RDIF-CT. However, RDIF-CT induced greater improvements in body composition (i.e., weight, FM, Fat% and WC (p < 0.05, p < 0.01, p < 0.01 and p < 0.05; respectively)) as well as greater decrease in lipid biomarkers (i.e., TC, TG and LDL (p < 0.01 for all)), inflammation (i.e., CRP (p < 0.05)), and liver damage (i.e., ASAT, ALAT and Gamma-GT (p < 0.01, p < 0.05 and p < 0.001; respectively)) compared to RDIF-NCT group pre-post intervention.

CONCLUSIONS

Our results suggest that a combination of RDIF and CT induces greater changes in body composition, lipid profile, inflammation and liver biomarkers compared to RDIF strategy alone.

CLINICAL TRIAL REGISTER

PACTR202203475387226.

摘要

背景和目的

我们研究了两种策略（斋月日间间歇性禁食“RDIF”策略与 RDIF 加同时训练计划“RDIF-CT”策略）对肥胖男性身体成分的积极影响，然后探讨了它们对代谢和炎症生物标志物的可能影响。

方法和结果

20 名年龄为 31.8±7.05 岁、BMI 为 33.1±4.2kg/m²、经常进行 RDIF 的肥胖男性被随机分为两组：RDIF-CT（n=10）和 RDIF 无训练组（RDIF-NCT）（n=10）。RDIF-CT 组参加了为期 4 周的高强度间歇训练（HIIT）与阻力训练相结合的方案。在 4 周 RDIF 前后评估身体成分、血糖、血脂谱、肝生物标志物和炎症。两组体重、脂肪量（FM）、脂肪百分比（Fat%）和腰围（WC）均显著下降，血糖、血脂谱和炎症均得到改善。RDIF-NCT 组的去脂体重显著下降（p<0.05），而 RDIF-CT 组则保持不变。然而，RDIF-CT 引起的身体成分改善更为显著（即体重、FM、Fat%和 WC（p<0.05、p<0.01、p<0.01 和 p<0.05；分别））以及血脂生物标志物（即 TC、TG 和 LDL（所有 p<0.01））、炎症（即 CRP（p<0.05））和肝损伤（即 ASAT、ALAT 和 Gamma-GT（p<0.01、p<0.05 和 p<0.001；分别））的降低也比 RDIF-NCT 组更为显著。