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Metformin facilitates osteogenic differentiation of bone marrow stromal cells through AMPK-dependent autophagy: an investigation into the healing of osteoporotic fractures in murine models.

作者信息

Du Daoguang, Hong Shan, Zhang Yanbin, Wang Ziyu, Li Hao, Gao Zhicheng

机构信息

Department of Orthopaedic Trauma, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, 453000, P.R. China.

Dengzhou Central Hospital, Henan Province, Dengzhou, Henan, 474150, P.R. China.

出版信息

J Orthop Surg Res. 2025 Jul 16;20(1):661. doi: 10.1186/s13018-025-06067-6.

DOI:10.1186/s13018-025-06067-6
PMID:40671012
Abstract
摘要

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本文引用的文献

1
Mechanistic Insights and Therapeutic Strategies in Osteoporosis: A Comprehensive Review.骨质疏松症的机制见解与治疗策略：全面综述
Biomedicines. 2024 Jul 23;12(8):1635. doi: 10.3390/biomedicines12081635.
2
Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies.骨质疏松性骨整合：治疗特征和工程策略。
Theranostics. 2024 Jun 17;14(10):3859-3899. doi: 10.7150/thno.96516. eCollection 2024.
3
CD4 and CD8 T cells reduce inflammation and promote bone healing in response to titanium implants.CD4 和 CD8 T 细胞可减少炎症反应，促进钛植入物引发的骨愈合。
Acta Biomater. 2024 Apr 15;179:385-397. doi: 10.1016/j.actbio.2024.03.022. Epub 2024 Mar 29.
4
Harnessing GMNP-loaded BMSC-derived EVs to target miR-3064-5p via MEG3 overexpression: Implications for diabetic osteoporosis therapy in rats.利用负载 GMNP 的骨髓间充质干细胞衍生的外泌体通过过表达 MEG3 靶向 miR-3064-5p：对大鼠糖尿病骨质疏松症治疗的影响。
Cell Signal. 2024 Jun;118:111055. doi: 10.1016/j.cellsig.2024.111055. Epub 2024 Jan 20.
5
Biomimetic cryogel promotes the repair of osteoporotic bone defects through altering the ROS niche via down-regulating the ROMO1.仿生水凝胶通过下调 ROMO1 改变 ROS 生态位促进骨质疏松性骨缺损的修复。
Int J Biol Macromol. 2024 Feb;257(Pt 1):128481. doi: 10.1016/j.ijbiomac.2023.128481. Epub 2023 Nov 30.
6
Estrogen deficiency impedes fracture healing despite eliminating the excessive absorption of the posterior callus in a semi-fixed distal tibial fracture mouse model.雌激素缺乏会阻碍骨折愈合，尽管它能消除半固定胫骨远端骨折小鼠模型中后骨痂的过度吸收。
BMC Musculoskelet Disord. 2023 Oct 10;24(1):803. doi: 10.1186/s12891-023-06929-2.
7
Global burden of hip fracture: The Global Burden of Disease Study.全球髋部骨折负担：全球疾病负担研究。
Osteoporos Int. 2024 Jan;35(1):41-52. doi: 10.1007/s00198-023-06907-3. Epub 2023 Sep 14.
8
Ameliorative Effects of Extracellular Vesicles Derived from Mesenchymal Stem Cells on Apoptosis and Differentiation of Osteoblasts Treated with CoCl.骨髓间充质干细胞来源的细胞外囊泡对 CoCl_2 处理的成骨细胞凋亡和分化的改善作用
Cell Reprogram. 2023 Jun;25(3):99-108. doi: 10.1089/cell.2023.0001. Epub 2023 May 15.
9
The use of metformin, sulfonylurea compounds and insulin and the risk of hip fractures in diabetic patients: a systematic review and meta-analysis of observational studies.二甲双胍、磺酰脲类化合物和胰岛素的使用与糖尿病患者髋部骨折风险的关系：观察性研究的系统评价和荟萃分析。
BMC Musculoskelet Disord. 2023 May 9;24(1):367. doi: 10.1186/s12891-023-06493-9.
10
Metformin promotes osteogenic differentiation and prevents hyperglycaemia-induced osteoporosis by suppressing PPARγ expression.二甲双胍通过抑制 PPARγ 的表达促进成骨分化并预防高血糖诱导的骨质疏松症。
Acta Biochim Biophys Sin (Shanghai). 2023 Mar 25;55(3):394-403. doi: 10.3724/abbs.2023043.