Hong Guizhen, Liu Fei
Nutriology Department, Guilin Rehabilitation and Rehabilitation Center of Joint Logistics Support Force, Guilin, 541000, China.
Sanatorium Department, Guilin Rehabilitation and Rehabilitation Center of Joint Logistics Support Force, No.88, Wanfu Road, Xiangshan District, Guilin, 541000, China.
J Cardiothorac Surg. 2025 Jul 16;20(1):303. doi: 10.1186/s13019-025-03543-2.
High-intensity interval training (HIIT) has emerged as a potential cardiac rehabilitation strategy for coronary heart disease (CHD) post-surgery, but its efficacy compared to moderate-intensity continuous training (MICT) remains uncertain.
This meta-analysis aimed to evaluate the effects of HIIT on cardiopulmonary function and quality of life in CHD patients post-PCI or CABG in comparison with MICT.
We systematically reviewed randomized controlled trials from PMID, Cochrane, Embase, Wanfang, and China National Knowledge Infrastructure (CNKI) databases comparing HIIT with MICT in CHD patients. Data on peak oxygen uptake (VO2peak), left ventricular ejection function (LVEF), heart rates, and quality of life were extracted and analyzed using random-or fixed-effects models based on heterogeneity.
HIIT significantly improved VOpeak by 1.678 mL/kg/min (95%CI = 1.082-2.275), increased LVEF by 2.831% (95%CI = 1.124-4.538), enhanced peak HR by 6.717 beats/min (95%CI = 5.111-8.323) compared to MICT. Resting HR did not differ significantly between groups. Quality of life (SMD = 0.132, 95%CI = 0.051-0.213, P = 0.001) was significantly elevated by HIIT, particularly in the physical domain. Subgroup analyses showed consistent benefits of HIIT across exercise durations and times.
HIIT effectively enhances cardiopulmonary function and quality of life in CHD post-surgery. HIIT may be a time-efficient alternative to MICT in cardiac rehabilitation programs. However, publication bias and high heterogeneity warrant caution in interpreting these results, indicating a need for further research.
高强度间歇训练（HIIT）已成为冠心病（CHD）术后一种潜在的心脏康复策略，但其与中等强度持续训练（MICT）相比的疗效仍不确定。
本荟萃分析旨在评估与MICT相比，HIIT对冠心病患者经皮冠状动脉介入治疗（PCI）或冠状动脉旁路移植术（CABG）后心肺功能和生活质量的影响。
我们系统回顾了来自PubMed（医学期刊数据库）、Cochrane、Embase、万方和中国知网（CNKI）数据库的随机对照试验，这些试验比较了冠心病患者中HIIT与MICT的效果。提取了关于峰值摄氧量（VO2peak）、左心室射血功能（LVEF）、心率和生活质量的数据，并根据异质性使用随机或固定效应模型进行分析。
与MICT相比，HIIT显著提高VOpeak 1.678 mL/kg/min（95%置信区间[CI]=1.082-2.275），增加LVEF 2.831%（95%CI=1.124-4.538），提高峰值心率6.717次/分钟（95%CI=5.111-8.323）。两组间静息心率无显著差异。HIIT显著提高了生活质量（标准化均数差[SMD]=0.132，95%CI=0.051-0.213，P=0.001），尤其是在身体领域。亚组分析显示，HIIT在不同运动持续时间和时段均有一致的益处。
HIIT有效增强了冠心病术后患者的心肺功能和生活质量。在心脏康复计划中，HIIT可能是一种比MICT更节省时间的替代方案。然而，发表偏倚和高异质性使得在解释这些结果时需谨慎，这表明需要进一步研究。
