Deng Shi-Kun, Wang Qing, Duan Shi-Jie, Yu Sheng-Hui
Department of Intensive Care Unit, Chengdu First People's Hospital/Chengdu Integrated TCM and Western Medicine Hospital, Chengdu 610000, Sichuan Province, China.
Department of Emergency, Chengdu First People's Hospital/Chengdu Integrated TCM and Western Medicine Hospital, Chengdu 610000, Sichuan Province, China.
World J Clin Cases. 2025 Jul 16;13(20):103842. doi: 10.12998/wjcc.v13.i20.103842.
Ethylene glycol (EG) poisoning is often caused by the accidental ingestion of antifreeze. EG is metabolized into glycolate and oxalate and may cause metabolic acidaemia, neurotoxicity, acute kidney injury, and death. A variety of EG poisoning case reports have been published, and we wrote this case report and literature review to summarize the clinical experience of patients who survived EG poisoning.
In this case report, a 55-year-old man developed EG poisoning after ingesting antifreeze by accident and experienced acute kidney injury, nervous system dysfunction and inhalation pneumonia. The timely use of ethanol for detoxification, initiation of haemodialysis, and protection of organ function are effective treatment methods for patients with antifreeze poisoning. The patient was discharged in the 3rd week after admission. When discharged, the patient did not report any discomfort, had stable vital signs, did not have fever or diarrhoea, and had improved liver and kidney functions.
A timely diagnosis, haemodialysis, and organ protection are the keys to the successful treatment of poisoned patients.
乙二醇(EG)中毒常因意外摄入防冻液所致。EG代谢为乙醇酸和草酸,可导致代谢性酸血症、神经毒性、急性肾损伤及死亡。已有多篇乙二醇中毒病例报告发表,我们撰写本病例报告及文献综述以总结乙二醇中毒幸存者的临床经验。
在本病例报告中,一名55岁男性意外摄入防冻液后发生乙二醇中毒,出现急性肾损伤、神经系统功能障碍及吸入性肺炎。及时使用乙醇解毒、启动血液透析及保护器官功能是防冻液中毒患者的有效治疗方法。患者入院第3周出院。出院时,患者未诉任何不适,生命体征平稳,无发热或腹泻,肝肾功能改善。
及时诊断、血液透析及器官保护是中毒患者成功治疗的关键。