非洲利益相关者对用于疟疾控制的基因驱动和转基因蚊子的知识、观点及风险认知：一项范围综述方案

Knowledge, Perspectives, and Risks Perceptions on Gene Drive and Genetically Modified Mosquitoes for Malaria Control among African Stakeholders: A Scoping Review Protocol.

作者信息

Sogodogo Abou, Diarra Samba, Keita Soumba, Diallo Idiatou, Hartley Sarah, Telly Nouhoum, Dolo Housséini, Sanogo Daouda, Kané Fousseyni, Tangara Cheick Oumar, Diakité Mahamadou, Sangho Oumar, Kayentao Kassoum, Fritz Hannah, Winch Peter J, Doumbia Seydou

机构信息

University Clinical Research Center/University of Sciences Techniques and Technologies of Bamako.

University of Clinical Research Center/University of Sciences Techniques and Technologies of Bamako.

出版信息

Res Sq. 2025 Jul 9:rs.3.rs-6048767. doi: 10.21203/rs.3.rs-6048767/v1.

DOI:10.21203/rs.3.rs-6048767/v1

PMID:40671811

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12265174/

Abstract

OBJECTIVE

The objective of this scoping review is to understand the knowledge and perspectives of African stakeholders regarding the use of gene drive mosquitoes in malaria control.

INTRODUCTION

The prospect of using gene drive and genetically modified mosquitoes as tools for malaria control is generating considerable debate, particularly with regard to its acceptance and implications among key stakeholders, as well as the nature of governance established in its management. This study aims to fill the gaps in understanding the views of African stakeholders on the risks associated with these mosquitoes.

INCLUSION CRITERIA

This review will include scientific articles and grey literature that explore the knowledge, perspectives, and risks perceptions of African stakeholders on the use of gene drive and genetically modified mosquitoes. Exclusions will apply to documents with restricted access, those addressing diseases other than malaria, and those involving stakeholders outside Africa.

METHODS

The search will be conducted across PubMed, Embase, Science Direct, Cochrane, and Google Scholar using index terms and keyword strategies tailored to each database. Documents will be selected in four stages: identification, duplicate removal, title and abstract screening, and full-text review for final inclusion. Screening will be conducted on Rayyan by two independent reviewers, with references managed in Zotero. Data extraction will include details on authorship, publication year, study objectives, design, methodology, sample size, findings, conclusions, and limitations. A thematic analysis of the extracted data will be conducted.

DISCUSSION

This scoping review will provide a clear understanding of the knowledge, perspectives, and risks perceived by African stakeholders regarding the use of gene drive and genetically modified mosquitoes in malaria control. The results will help to improve communities' engagement, which is crucial to the success of this technology.

REGISTRATION

This protocol is registered on the Open Science Framework (OSF) (https://osf.io/4kz85).

摘要

目的

本综述的目的是了解非洲利益相关者对使用基因驱动蚊子控制疟疾的知识和观点。

引言

使用基因驱动和转基因蚊子作为疟疾控制工具的前景引发了广泛的争论，特别是在关键利益相关者对其接受程度和影响以及管理中建立的治理性质方面。本研究旨在填补在理解非洲利益相关者对这些蚊子相关风险看法方面的空白。

纳入标准

本综述将包括探讨非洲利益相关者对使用基因驱动和转基因蚊子的知识、观点和风险认知的科学文章和灰色文献。排除适用于访问受限的文件、涉及疟疾以外疾病的文件以及涉及非洲以外利益相关者的文件。

方法

将在PubMed、Embase、Science Direct、Cochrane和谷歌学术上进行搜索，使用针对每个数据库量身定制的索引词和关键词策略。文件将分四个阶段进行选择：识别、去除重复项、标题和摘要筛选以及全文审查以最终纳入。筛选将由两名独立评审员在Rayyan上进行，参考文献在Zotero中管理。数据提取将包括作者、出版年份、研究目标、设计、方法、样本量、研究结果、结论和局限性等详细信息。将对提取的数据进行主题分析。